MAP3K3 and BRCA1

Number of citations of the paper that reports this interaction (PMID 15205325)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		MAP3K3	BRCA1
Gene Name		mitogen-activated protein kinase kinase kinase 3	breast cancer 1, early onset
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Ubiquitin Ligase Complex Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Gamma-tubulin Ring Complex Ribonucleoprotein Complex BRCA1-BARD1 Complex Protein Complex BRCA1-A Complex
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	DNA Binding Damaged DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Androgen Receptor Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Postreplication Repair Double-strand Break Repair Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase III Promoter Fatty Acid Biosynthetic Process Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Chromosome Segregation Centrosome Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Dosage Compensation By Inactivation Of X Chromosome Response To Ionizing Radiation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Chordate Embryonic Development Response To Estrogen Regulation Of DNA Methylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Cell Cycle Arrest Cellular Response To Tumor Necrosis Factor Cellular Response To Indole-3-methanol Protein K6-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4-K16 Acetylation
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	312 interactors: ABL1 ABLIM3 ACACA ACTG1 ACTN3 AHR AKT1 ALDH1A1 ALS2CR11 ANTXR1 AP1M1 APLP2 AR ARNT ASH2L ATF1 ATM ATP1B1 ATP1B3 ATR ATRIP AURKA AURKC BABAM1 BAP1 BARD1 BRAP BRAT1 BRCA2 BRCC3 BRIP1 BRSK1 C22orf29 CABYR CASP3 CCDC120 CCNA1 CCNA2 CCNB1 CCND1 CDK1 CDK16 CDK2 CDK4 CDK5 CDK7 CDK9 CDKN2D CEP57L1 CHEK1 CHEK2 CLSPN CNRIP1 CNTLN CNTN4 COL1A1 COMMD1 CREBBP CRIPAK CRY2 CRYZL1 CSNK1D CSNK2A1 CSNK2B CSTF1 CTBP1 CTCFL CTNNB1 CUBN CWF19L2 DALRD3 DBF4 DCLRE1C DCN DDX24 DES DHPS DHX9 DNAJA1 DNAJA3 DNAJB1 DNHD1 DYNC1H1 E2F1 E2F4 EED EIF3B EIF4A2 EIF5B ELK1 ELK4 ENO1 EP300 ERCC6 ERO1LB ESR1 ETS1 ETV5 EZH2 FAM161A FAM175A FAM184A FANCA FANCD2 FHL2 FLI1 FXR2 GCC1 GFI1B GGN GOLGA8DP GTF3C4 GUSBP1 H2AFX H2AFY HDAC1 HDAC2 HECTD3 HERC2 HGF HIBADH HIST1H2AB HIST2H2AC HIVEP1 HNRNPC HNRNPD HORMAD1 HSPA14 HSPA8 HSPD1 IFI16 INPP1 ITIH5 JAK1 JAK2 JUN JUNB JUND JUP KAT2A KAT5 KDM1A KIF1B KPNA2 KPNA6 LCK LCMT1 LDHC LMNTD1 LMO4 LONRF1 MAN2C1 MAP3K1 MAP3K14 MAP3K3 MAP4K4 MARCKSL1 MDC1 MED1 MED21 MID2 MLH1 MNAT1 MRE11A MSH2 MSH3 MSH6 MYC MYOZ1 NBN NCOA2 NCOA3 ND1 NELFB NFKB1 NFYA NKAPL NMI NPC2 NRIP1 NUFIP1 NUP153 OBSCN OLA1 PEG3 PEX5 PGR PHF12 PIAS1 PIAS4 PIK3R1 PILRB PISD POLR2A POLR2H POLR2K POM121 POMGNT1 POU2F1 PPHLN1 PPP1CA PPP1CB PPP1R13B PPP2R5C PREP PRKAG3 PRKDC PRMT1 PRPF3 PSAP PSMA6 PSMD9 PSMG1 RAD51 RANBP9 RB1 RBBP4 RBBP7 RBBP8 RBL1 RBL2 RBX1 RELA RFC1 RNF216 RPGRIP1 RPL31 RTKN2 RUNX1T1 RWDD2B RWDD4 SDK2 SETX SHFM1 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMC1A SNRNP200 SNX3 SNX6 SOX30 SP1 SPATA4 SRC SSFA2 SSX2IP STAC2 STAT1 STAT3 STAT5A SUMO1 SYT6 TARS TATDN2 TCEA2 TCEANC TCEB3 TCTEX1D2 TEX101 THOC3 TLE4 TMPRSS12 TNS2 TOP2A TP53 TP53BP1 TPTE2 TRIM24 TRIM46 TRIM74 TRRAP TSEN54 TSGA10IP TUBA4A TUBB TUBG1 TULP2 TXLNA UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J1 UBE2K UBE2L3 UBE2N UBE2T UBE2W UBE3A UBXN1 USF2 USH2A USP2 VCP WBSCR16 WDR6 WNT2B XIAP XRCC1 XRCC5 YY1 ZNF280D ZNF350 ZNF423 ZSCAN21
Entrez ID		4215	672
HPRD ID		03965	00218
Ensembl ID		ENSG00000198909	ENSG00000012048
Uniprot IDs		J3KRN4 J3QRB6 Q99759	E9PFC7 E9PFZ0 P38398 Q1RMC1
PDB IDs		2C60 2JRH 2O2V 2PPH	1JM7 1JNX 1N5O 1OQA 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair Cell Cycle Process Regulation Of Cell Cycle Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Response To Abiotic Stimulus Transcription, DNA-templated Gene Expression Regulation Of Gene Expression DNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Cellular Response To Stimulus DNA Damage Checkpoint Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Organelle Organization Response To Stimulus
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	1b 53bp1 activators associates binds brct cbp cip1 domain emphasized hat homology inherited link manners maps ovarian p100 p110 p21waf1 p53 promoters splice stimulate stimulates suppression transactivation
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	1b 53bp1 activators associates binds brct cbp cip1 domain emphasized hat homology inherited link manners maps ovarian p100 p110 p21waf1 p53 promoters splice stimulate stimulates suppression transactivation
Tagcloud (Intersection) ?