MAP3K3 and TRAF7

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vivo)

		MAP3K3	TRAF7
Gene Name		mitogen-activated protein kinase kinase kinase 3	TNF receptor-associated factor 7, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Ubiquitin Ligase Complex Nucleus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKKK Activity Transcription, DNA-templated Apoptotic Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Protein Sumoylation Positive Regulation Of MAPK Cascade Cellular Response To Interleukin-6 Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS		Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	10 interactors: CYLD MAP3K3 RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6
Entrez ID		4215	84231
HPRD ID		03965	06977
Ensembl ID		ENSG00000198909	ENSG00000131653
Uniprot IDs		J3KRN4 J3QRB6 Q99759	B3KQY7 Q6Q0C0
PDB IDs		2C60 2JRH 2O2V 2PPH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Cellular Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Positive Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Catabolic Process Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Immune Response Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination
Tagcloud (Difference) ?		11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a	adaptive ap associates brings cytoplasmic humoral identifies ikappab influences innate interacting kappab lys lysosomal member microarray modulator necrosis nemo nf noncanonical p65 physically polyubiquitination promotes rela transducers ubiquitination
Tagcloud (Intersection) ?