KDM6A and BMP15

Data Source: HiPPIP (Novel)

		KDM6A	BMP15
Name		lysine demethylase 6A	bone morphogenetic protein 15
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Female Gamete Generation
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Diseases		None	Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		7 novel interactors: AKAP4 BMP15 ELK1 HSD17B10 MAGED2 RBM3 ZNF157	1 novel interactors: KDM6A
Interacting Genes		15 interacting genes: CREBBP GSC2 H3-4 H3C1 H3C14 HUNK MEOX2 MTDH NKX2-5 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2	2 interacting genes: BMPR1B GDF9
Entrez ID		7403	9210
HPRD ID		02131	02216
Ensembl ID		ENSG00000147050	ENSG00000130385
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	O95972
PDB IDs		3AVR 3AVS 6FUK 6FUL	Not available
GO Terms Enriched among Interactors		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process	HFE-transferrin Receptor Complex Developmental Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Endochondral Bone Morphogenesis Regulation Of Female Gonad Development Regulation Of Progesterone Secretion Oocyte Growth Histone H3K27me2/H3K27me3 Demethylase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors MLL3/4 Complex Cartilage Condensation Positive Regulation Of Chondrocyte Differentiation BMP Binding Retinal Ganglion Cell Axon Guidance Ovulation Cycle Histone Demethylase Activity Cell Aggregation Enzyme-linked Receptor Protein Signaling Pathway Chondrocyte Development Histone Methyltransferase Complex Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Bone Morphogenesis Ovulation Cycle Process Positive Regulation Of Bone Mineralization Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Biomineral Tissue Development SMAD Binding Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification