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KDM6A
Gene Name
lysine (K)-specific demethylase 6A
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Identical Protein Binding
Metal Ion Binding
Dioxygenase Activity
Histone Demethylase Activity (H3-K27 Specific)
Biological Process
In Utero Embryonic Development
Neural Tube Closure
Heart Morphogenesis
Respiratory System Process
Chromatin Organization
Regulation Of Gene Expression
Somite Rostral/caudal Axis Specification
Multicellular Organism Growth
Mesodermal Cell Differentiation
Notochord Morphogenesis
Histone H3-K4 Methylation
Oxidation-reduction Process
Canonical Wnt Signaling Pathway
Histone H3-K27 Demethylation
Pathways
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions
8 interactors:
HIST1H3A
HIST2H3C
HIST3H3
NKX2-5
SMAD9
SRF
TBX5
TLE1
Entrez ID
7403
HPRD ID
02131
Ensembl ID
ENSG00000147050
Uniprot IDs
F5H5V6
F5H6S1
F8W8R6
O15550
Q59HG3
PDB IDs
3AVR
3AVS
Enriched GO Terms of Interacting Partners
?
Bundle Of His Development
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cardioblast Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cardiac Muscle Cell Differentiation
DNA Methylation On Cytosine
Cardiac Ventricle Formation
Cardiac Chamber Formation
Cardiac Conduction System Development
Nitrogen Compound Metabolic Process
Cardiocyte Differentiation
Gene Expression
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Chromatin Silencing At RDNA
Coronary Vasculature Development
Cardiac Chamber Development
Heart Trabecula Formation
Positive Regulation Of DNA-templated Transcription, Initiation
Atrial Septum Morphogenesis
Atrial Septum Development
Regulation Of DNA-templated Transcription, Initiation
Cardiac Myofibril Assembly
Cardiac Muscle Tissue Development
Heart Trabecula Morphogenesis
Regulation Of Transcription, DNA-templated
Heart Morphogenesis
Regulation Of Nucleic Acid-templated Transcription
Striated Muscle Cell Differentiation
Regulation Of RNA Biosynthetic Process
Cardiac Atrium Morphogenesis
Tube Development
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Chromatin Silencing
Regulation Of Developmental Growth
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Differentiation
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Trabecula Morphogenesis
Striated Muscle Tissue Development
Regulation Of Transcription From RNA Polymerase II Promoter
Muscle Cell Differentiation
Sarcomere Organization
Positive Regulation Of Stem Cell Differentiation
Ventricular Cardiac Muscle Tissue Development
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clin
clinicopathologic
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ercc2
exome
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multimodality
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noncarriers
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ptn
res
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somatic
staging
suboptimal
tsc1
unc5c
undiscovered
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warranted