KDM6A and ZNF157

Data Source: HiPPIP (Novel)

		KDM6A	ZNF157
Name		lysine demethylase 6A	zinc finger protein 157
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression	Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Generic Transcription Pathway
GWAS		No GWAS studies recorded	Optic nerve measurement (disc area) ( 20395239 )
Novel Interactors		7 novel interactors: AKAP4 BMP15 ELK1 HSD17B10 MAGED2 RBM3 ZNF157	1 novel interactors: KDM6A
Interacting Genes		15 interacting genes: CREBBP GSC2 H3-4 H3C1 H3C14 HUNK MEOX2 MTDH NKX2-5 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2	None recorded
Entrez ID		7403	7712
HPRD ID		02131	02064
Ensembl ID		ENSG00000147050	ENSG00000147117
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	P51786
PDB IDs		3AVR 3AVS 6FUK 6FUL	Not available
GO Terms Enriched among Interactors		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Histone H3K27me2/H3K27me3 Demethylase Activity MLL3/4 Complex Histone Demethylase Activity Histone Methyltransferase Complex Chromatin DNA Binding Dioxygenase Activity