KDM6A and TBX5

Number of citations of the paper that reports this interaction (PMID 22192413)
31

Data Source:
BioGRID (two hybrid)

		KDM6A	TBX5
Gene Name		lysine (K)-specific demethylase 6A	T-box 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Identical Protein Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Respiratory System Process Chromatin Organization Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Multicellular Organism Growth Mesodermal Cell Differentiation Notochord Morphogenesis Histone H3-K4 Methylation Oxidation-reduction Process Canonical Wnt Signaling Pathway Histone H3-K27 Demethylation	Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of Execution Phase Of Apoptosis
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Blood pressure ( 21909110) Diastolic blood pressure ( 19430479) Electrocardiographic traits ( 20062063) Mammographic density ( 22532574) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255) Prostate cancer ( 23535732) Ventricular conduction ( 21076409) Visceral fat ( 22589738)
Protein-Protein Interactions		8 interactors: HIST1H3A HIST2H3C HIST3H3 NKX2-5 SMAD9 SRF TBX5 TLE1	4 interactors: GATA4 KAT5 KDM6A NKX2-5
Entrez ID		7403	6910
HPRD ID		02131	03372
Ensembl ID		ENSG00000147050	ENSG00000089225
Uniprot IDs		F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3	Q99593
PDB IDs		3AVR 3AVS	2X6U 2X6V
Enriched GO Terms of Interacting Partners?		Bundle Of His Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cardiac Muscle Cell Differentiation DNA Methylation On Cytosine Cardiac Ventricle Formation Cardiac Chamber Formation Cardiac Conduction System Development Nitrogen Compound Metabolic Process Cardiocyte Differentiation Gene Expression Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing At RDNA Coronary Vasculature Development Cardiac Chamber Development Heart Trabecula Formation Positive Regulation Of DNA-templated Transcription, Initiation Atrial Septum Morphogenesis Atrial Septum Development Regulation Of DNA-templated Transcription, Initiation Cardiac Myofibril Assembly Cardiac Muscle Tissue Development Heart Trabecula Morphogenesis Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Striated Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process Cardiac Atrium Morphogenesis Tube Development Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Chromatin Silencing Regulation Of Developmental Growth Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Trabecula Morphogenesis Striated Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Differentiation Sarcomere Organization Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development	Positive Regulation Of Cardioblast Differentiation Canonical Wnt Signaling Pathway Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Heart Morphogenesis Atrial Septum Development Wnt Signaling Pathway Cardiac Atrium Morphogenesis Embryonic Organ Morphogenesis Cardiac Muscle Tissue Growth Epithelial Tube Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Tube Morphogenesis Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Pattern Specification Process Embryonic Organ Development Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Morphogenesis Of An Epithelium Determination Of Heart Left/right Asymmetry Heart Development Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Regulation Of Growth Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Embryonic Morphogenesis Tissue Morphogenesis Organ Growth Tube Development Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation
Tagcloud ?		aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Difference) ?		aacr bladder brca2 carriers clin clinicopathologic discovering drivers ercc2 exome fancd2 multimodality mutational noncarriers palb2 perioperative pt2 ptn res resected rfs somatic staging suboptimal tsc1 unc5c undiscovered usage warranted	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Intersection) ?