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KDM6A and HIST2H3C
Number of citations of the paper that reports this interaction (PMID
21575637
)
2
Data Source:
BioGRID
(enzymatic study)
KDM6A
HIST2H3C
Gene Name
lysine (K)-specific demethylase 6A
histone cluster 2, H3c
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Histone Methyltransferase Complex
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Identical Protein Binding
Metal Ion Binding
Dioxygenase Activity
Histone Demethylase Activity (H3-K27 Specific)
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
In Utero Embryonic Development
Neural Tube Closure
Heart Morphogenesis
Respiratory System Process
Chromatin Organization
Regulation Of Gene Expression
Somite Rostral/caudal Axis Specification
Multicellular Organism Growth
Mesodermal Cell Differentiation
Notochord Morphogenesis
Histone H3-K4 Methylation
Oxidation-reduction Process
Canonical Wnt Signaling Pathway
Histone H3-K27 Demethylation
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
8 interactors:
HIST1H3A
HIST2H3C
HIST3H3
NKX2-5
SMAD9
SRF
TBX5
TLE1
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
Entrez ID
7403
126961
HPRD ID
02131
11822
Ensembl ID
ENSG00000147050
Uniprot IDs
F5H5V6
F5H6S1
F8W8R6
O15550
Q59HG3
Q71DI3
PDB IDs
3AVR
3AVS
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
Enriched GO Terms of Interacting Partners
?
Bundle Of His Development
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cardioblast Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cardiac Muscle Cell Differentiation
DNA Methylation On Cytosine
Cardiac Ventricle Formation
Cardiac Chamber Formation
Cardiac Conduction System Development
Nitrogen Compound Metabolic Process
Cardiocyte Differentiation
Gene Expression
Positive Regulation Of Transcription Via Serum Response Element Binding
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Chromatin Silencing At RDNA
Coronary Vasculature Development
Cardiac Chamber Development
Heart Trabecula Formation
Positive Regulation Of DNA-templated Transcription, Initiation
Atrial Septum Morphogenesis
Atrial Septum Development
Regulation Of DNA-templated Transcription, Initiation
Cardiac Myofibril Assembly
Cardiac Muscle Tissue Development
Heart Trabecula Morphogenesis
Regulation Of Transcription, DNA-templated
Heart Morphogenesis
Regulation Of Nucleic Acid-templated Transcription
Striated Muscle Cell Differentiation
Regulation Of RNA Biosynthetic Process
Cardiac Atrium Morphogenesis
Tube Development
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Chromatin Silencing
Regulation Of Developmental Growth
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Differentiation
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Trabecula Morphogenesis
Striated Muscle Tissue Development
Regulation Of Transcription From RNA Polymerase II Promoter
Muscle Cell Differentiation
Sarcomere Organization
Positive Regulation Of Stem Cell Differentiation
Ventricular Cardiac Muscle Tissue Development
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Tagcloud
?
aacr
bladder
brca2
carriers
clin
clinicopathologic
discovering
drivers
ercc2
exome
fancd2
multimodality
mutational
noncarriers
palb2
perioperative
pt2
ptn
res
resected
rfs
somatic
staging
suboptimal
tsc1
unc5c
undiscovered
usage
warranted
Tagcloud (Difference)
?
aacr
bladder
brca2
carriers
clin
clinicopathologic
discovering
drivers
ercc2
exome
fancd2
multimodality
mutational
noncarriers
palb2
perioperative
pt2
ptn
res
resected
rfs
somatic
staging
suboptimal
tsc1
unc5c
undiscovered
usage
warranted
Tagcloud (Intersection)
?