PAPPA and C3

Number of citations of the paper that reports this interaction (PMID 6203109)
1

Data Source:
HPRD (in vitro)

		PAPPA	C3
Gene Name		pregnancy-associated plasma protein A, pappalysin 1	complement component 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Proteolysis Female Pregnancy Cell Differentiation Cellular Protein Metabolic Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Height ( 20881960 18391950)	Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)
Protein-Protein Interactions		10 interactors: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4
Entrez ID		5069	718
HPRD ID		01448	00400
Ensembl ID		ENSG00000182752	ENSG00000125730
Uniprot IDs		Q13219 Q7Z613 Q86YM8 Q8IWT8	P01024
PDB IDs			1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nodal Signaling Pathway Embryonic Foregut Morphogenesis Tissue Development Foregut Morphogenesis Paraxial Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA In Utero Embryonic Development Transcription Initiation From RNA Polymerase II Promoter Pericardium Development Regulation Of Cellular Component Organization Regulation Of Cellular Response To Growth Factor Stimulus Skeletal System Development Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Gene Silencing By MiRNA DNA-templated Transcription, Initiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Developmental Growth SMAD Protein Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Kidney Development	Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion
Tagcloud ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible	accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Difference) ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible	accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Intersection) ?