PAPPA and IGFBP4

Number of citations of the paper that reports this interaction (PubMedID 12241545)
49

Data Source:
HPRD (in vitro)

		PAPPA	IGFBP4
Description		pappalysin 1	insulin like growth factor binding protein 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Cell Surface Receptor Signaling Pathway Female Pregnancy	MAPK Cascade Regulation Of Cell Growth Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Growth Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 18391950 20881960 28552196) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)	Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		12 interacting genes: ATF7IP C3 CREBBP IGFBP4 KLHL20 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	9 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A MEX3A PAPPA SUV39H1 TF
Entrez ID		5069	3487
HPRD ID		01448	00900
Ensembl ID		ENSG00000182752	ENSG00000141753
Uniprot IDs		B4DTA8 Q13219 Q7Z613	P22692
PDB IDs		7UFG 7Y5N 7Y5Q 8A7D 8A7E 8D8O 8HGG 8HGH	1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pericardium Development Trophoblast Cell Migration Intracellular Signaling Cassette Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Lens Fiber Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Homeostatic Process R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Chromatin Binding DNA-binding Transcription Factor Binding MiRNA Processing Endoderm Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction Ureteric Bud Development Negative Regulation Of Ossification Tau Protein Binding Epithelium Development Positive Regulation Of Multicellular Organismal Process Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development SMAD Binding Mesoderm Formation Protein Domain Specific Binding Transcription Coactivator Binding Phosphatase Binding Positive Regulation Of Cell Communication C5L2 Anaphylatoxin Chemotactic Receptor Binding	Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Epigenetic Programming Of Gene Expression Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Region Positive Regulation Of Neural Precursor Cell Proliferation Epigenetic Regulation Of Gene Expression Negative Regulation Of Oocyte Development Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Regulation Of Developmental Growth Striated Muscle Cell Differentiation Aspartic-type Peptidase Activity Endopeptidase Activity Extracellular Space Intracellular Glucose Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Trophectodermal Cell Proliferation Epithelial To Mesenchymal Transition Insulin Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Organ Growth Regulation Of Neural Precursor Cell Proliferation Mannokinase Activity Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of T Cell Proliferation Muscle Cell Development Glycolate Metabolic Process Regulation Of Glucose Metabolic Process Muscle Cell Differentiation Mesenchymal Cell Differentiation ENoSc Complex Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ficolin-1-rich Granule Lumen Insulin Catabolic Process Insulin Receptor Recycling
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