PAPPA and IGFBP4

Number of citations of the paper that reports this interaction (PMID 12241545)
7

Data Source:
HPRD (in vitro)

		PAPPA	IGFBP4
Gene Name		pregnancy-associated plasma protein A, pappalysin 1	insulin-like growth factor binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding	Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Female Pregnancy Cell Differentiation Cellular Protein Metabolic Process	Skeletal System Development Regulation Of Cell Growth DNA Metabolic Process Inflammatory Response Signal Transduction Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Height ( 20881960 18391950)	Height ( 23563607)
Protein-Protein Interactions		10 interactors: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	8 interactors: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF
Entrez ID		5069	3487
HPRD ID		01448	00900
Ensembl ID		ENSG00000182752	ENSG00000141753
Uniprot IDs		Q13219 Q7Z613 Q86YM8 Q8IWT8	P22692
PDB IDs			1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nodal Signaling Pathway Embryonic Foregut Morphogenesis Tissue Development Foregut Morphogenesis Paraxial Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA In Utero Embryonic Development Transcription Initiation From RNA Polymerase II Promoter Pericardium Development Regulation Of Cellular Component Organization Regulation Of Cellular Response To Growth Factor Stimulus Skeletal System Development Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Gene Silencing By MiRNA DNA-templated Transcription, Initiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Developmental Growth SMAD Protein Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Kidney Development	Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Hormone Biosynthetic Process Blood Coagulation Hemostasis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Body Fluid Levels Positive Regulation Of Activated T Cell Proliferation Wound Healing Platelet Activation Regulation Of Hormone Biosynthetic Process Response To Wounding Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Muscle Cell Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Exocytosis Exocrine System Development Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of T Cell Proliferation Regulation Of DNA Binding Pancreas Development Muscle Structure Development Secretion By Cell Regulation Of Glucose Metabolic Process Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Secretion Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Muscle Cell Development
Tagcloud ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible	absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would
Tagcloud (Difference) ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible	absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would
Tagcloud (Intersection) ?