PAPPA and PRG2

Number of citations of the paper that reports this interaction (PMID 10913121)
12

Data Source:
HPRD (in vitro)

		PAPPA	PRG2
Gene Name		pregnancy-associated plasma protein A, pappalysin 1	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane	Extracellular Region Transport Vesicle Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding	Heparin Binding Carbohydrate Binding
	Biological Process	Proteolysis Female Pregnancy Cell Differentiation Cellular Protein Metabolic Process	Defense Response To Nematode Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Defense Response To Bacterium
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Height ( 20881960 18391950)	Crohn's disease ( 22412388)
Protein-Protein Interactions		10 interactors: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	7 interactors: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48
Entrez ID		5069	5553
HPRD ID		01448	09283
Ensembl ID		ENSG00000182752
Uniprot IDs		Q13219 Q7Z613 Q86YM8 Q8IWT8	A6XMW0 P13727
PDB IDs			1H8U 2BRS
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nodal Signaling Pathway Embryonic Foregut Morphogenesis Tissue Development Foregut Morphogenesis Paraxial Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA In Utero Embryonic Development Transcription Initiation From RNA Polymerase II Promoter Pericardium Development Regulation Of Cellular Component Organization Regulation Of Cellular Response To Growth Factor Stimulus Skeletal System Development Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Gene Silencing By MiRNA DNA-templated Transcription, Initiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Developmental Growth SMAD Protein Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Kidney Development	Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cell Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Peptidyl-tyrosine Phosphorylation Female Pregnancy Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Glucose Import Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Cell Death Positive Regulation Of Glucose Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Glucose Import Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Negative Regulation Of Signaling Negative Regulation Of Hydrolase Activity Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Sodium Ion Transport Positive Regulation Of Signal Transduction Positive Regulation Of Phospholipase Activity Regulation Of Phosphorylation Reproductive Process Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Phospholipase Activity Regulation Of Oxidoreductase Activity Developmental Cell Growth Positive Regulation Of Peptidyl-serine Phosphorylation
Tagcloud ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible
Tagcloud (Difference) ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible
Tagcloud (Intersection) ?