PAPPA and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 26687681)
0

Data Source:
BioGRID (two hybrid)

		PAPPA	KLHL20
Description		pappalysin 1	kelch like family member 20
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Proteolysis Cell Surface Receptor Signaling Pathway Female Pregnancy	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591) Height ( 18391950 20881960 28552196) Hip circumference adjusted for BMI ( 34021172) Intralaminar thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401)	Feeling miserable ( 29500382)
Interacting Genes		12 interacting genes: ATF7IP C3 CREBBP IGFBP4 KLHL20 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		5069	27252
HPRD ID		01448	13918
Ensembl ID		ENSG00000182752	ENSG00000076321
Uniprot IDs		B4DTA8 Q13219 Q7Z613	Q9Y2M5
PDB IDs		7UFG 7Y5N 7Y5Q 8A7D 8A7E 8D8O 8HGG 8HGH	5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pericardium Development Trophoblast Cell Migration Intracellular Signaling Cassette Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Transforming Growth Factor Beta Receptor Binding Lens Fiber Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Homeostatic Process R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Chromatin Binding DNA-binding Transcription Factor Binding MiRNA Processing Endoderm Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction Ureteric Bud Development Negative Regulation Of Ossification Tau Protein Binding Epithelium Development Positive Regulation Of Multicellular Organismal Process Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development SMAD Binding Mesoderm Formation Protein Domain Specific Binding Transcription Coactivator Binding Phosphatase Binding Positive Regulation Of Cell Communication C5L2 Anaphylatoxin Chemotactic Receptor Binding	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I
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