PAPPA

Gene Name		pregnancy-associated plasma protein A, pappalysin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Proteolysis Female Pregnancy Cell Differentiation Cellular Protein Metabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Height ( 20881960 18391950)
Protein-protein Interactions		10 interactors: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		5069
HPRD ID		01448
Ensembl ID		ENSG00000182752
Uniprot IDs		Q13219 Q7Z613 Q86YM8 Q8IWT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Primary MiRNA Processing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nodal Signaling Pathway Embryonic Foregut Morphogenesis Tissue Development Foregut Morphogenesis Paraxial Mesoderm Development Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA In Utero Embryonic Development Transcription Initiation From RNA Polymerase II Promoter Pericardium Development Regulation Of Cellular Component Organization Regulation Of Cellular Response To Growth Factor Stimulus Skeletal System Development Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Gene Silencing By MiRNA DNA-templated Transcription, Initiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Developmental Growth SMAD Protein Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Stem Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Metabolic Process Kidney Development
Tagcloud ?		alleviate altering alternating american capillaries ccl2 closer coat concave convex dawley diepoxide endometrium eosin follicles ginseng glands hematoxylin nell1 ovarian pla2g4a pof premature sprague stc2 uterine vcd vinylcyclohexene visible