ATR and EEF1E1

Number of citations of the paper that reports this interaction (PMID 15680327)
26

Data Source:
HPRD (in vitro, in vivo)

		ATR	EEF1E1
Gene Name		ATR serine/threonine kinase	eukaryotic translation elongation factor 1 epsilon 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	Protein Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	TRNA Aminoacylation For Protein Translation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	4 interactors: ATM ATR CALCOCO2 NAT9
Entrez ID		545	9521
HPRD ID		08369	10931
Ensembl ID		ENSG00000175054	ENSG00000124802
Uniprot IDs		Q13535	O43324
PDB IDs			2UZ8 4BJV 4BJW
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	Replicative Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Gamma Radiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To Heat Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Heat Peptidyl-serine Phosphorylation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Response To DNA Damage Stimulus Response To Ionizing Radiation Cellular Response To Radiation DNA Damage Checkpoint Double-strand Break Repair Response To Temperature Stimulus Protein Autophosphorylation Cell Cycle Checkpoint DNA Recombination Pre-B Cell Allelic Exclusion Aging Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Pre-B Cell Differentiation Histone MRNA Catabolic Process Regulation Of Protein Processing Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Immature B Cell Differentiation Response To Radiation DNA Damage Induced Protein Phosphorylation Negative Regulation Of Cell Cycle G2/M Phase Transition Lipoprotein Catabolic Process Negative Regulation Of B Cell Proliferation Mitotic G2 DNA Damage Checkpoint Histone-serine Phosphorylation Histone MRNA Metabolic Process DNA Repair Phosphatidylinositol-3-phosphate Biosynthetic Process V(D)J Recombination Regulation Of Proteolysis G2 DNA Damage Checkpoint Mitotic Spindle Assembly Checkpoint Histone Phosphorylation
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Intersection) ?