ATR and TREX1

Number of citations: 0 (PubMedID 11721054)
Data Source: HPRD (in vitro, in vivo)

		ATR	TREX1
Name		ATR checkpoint kinase	three prime repair exonuclease 1
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Membrane Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity DNA Binding, Bending Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair	DNA Damage Checkpoint Signaling Blood Vessel Development Kidney Development Adaptive Immune Response Organ Or Tissue Specific Immune Response Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Inflammatory Response Immune Response DNA Damage Response Determination Of Adult Lifespan Response To UV Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Regulation Of Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Retrotransposition Regulation Of Type I Interferon Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To UV Cellular Response To Interferon-beta Apoptotic Cell Clearance Regulation Of Cellular Respiration Innate Immune Response Regulation Of Innate Immune Response Establishment Of Protein Localization Negative Regulation Of Innate Immune Response Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Type I Interferon Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways		Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs		Ceralasertib	None
Diseases		Alveolar rhabdomyosarcoma Seckel syndrome	Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS		Eosinophil count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 29403010 32888494 ) Red cell distribution width ( 28957414 32888494 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Obesity-related traits ( 23251661 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 )
Interacting Genes		58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5	48 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC71A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1
Entrez ID		545	11277
HPRD ID		08369	09423
Ensembl ID		ENSG00000175054	ENSG00000213689
Uniprot IDs		Q13535	Q5TZT0 Q9NSU2
PDB IDs		5YZ0	7TQN 7TQO 7TQP 7TQQ 8VL7 9AVA
GO Terms Enriched among Interactors		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Histone H2AXS139 Kinase Activity Membrane Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Double-strand Break Repair Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Somatic Cell DNA Recombination Positive Regulation Of Telomerase Catalytic Core Complex Assembly Telomere Maintenance DNA Damage Checkpoint Signaling Protein Localization To Chromosome DNA-dependent Protein Kinase Activity Telomere Organization Double-strand Break Repair Via Homologous Recombination Mitotic DNA Damage Checkpoint Signaling Recombinational Repair DNA Recombination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Somatic Recombination Of Immunoglobulin Gene Segments Protein Binding MutLalpha Complex Binding Negative Regulation Of Telomere Capping Somatic Diversification Of Immunoglobulins Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Organization Negative Regulation Of Cell Cycle Phase Transition Response To Gamma Radiation Mitotic G2/M Transition Checkpoint DNA Repair Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Telomere Capping Response To Ionizing Radiation Regulation Of Double-strand Break Repair Replicative Senescence Regulation Of Cellular Response To Heat DNA Replication Endoplasmic Reticulum Damaged DNA Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA-templated DNA Replication Initiation DNA Metabolic Process Negative Regulation Of Cell Cycle Process Pexophagy Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle