ATR and E2F1

Number of citations of the paper that reports this interaction (PMID 11459832)
103

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		ATR	E2F1
Gene Name		ATR serine/threonine kinase	E2F transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ
Entrez ID		545	1869
HPRD ID		08369	01806
Ensembl ID		ENSG00000175054	ENSG00000101412
Uniprot IDs		Q13535	Q01094 Q9BSD8
PDB IDs			1H24 1O9K 2AZE
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Intersection) ?