ATR and XPA

Number of citations of the paper that reports this interaction (PMID 16540648)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ATR	XPA
Gene Name		ATR serine/threonine kinase	xeroderma pigmentosum, complementation group A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Golgi Apparatus Intercellular Bridge
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Multicellular Organism Growth
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	20 interactors: ATM ATR DDB1 DDB2 ERCC1 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PRKDC RASSF1 RPA1 RPA2 RPA4 TRIM27 XAB2
Entrez ID		545	7507
HPRD ID		08369	02045
Ensembl ID		ENSG00000175054	ENSG00000136936
Uniprot IDs		Q13535	P23025
PDB IDs			1D4U 1XPA 2JNW
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	DNA Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal DNA Recombination Transcription-coupled Nucleotide-excision Repair Response To Stress Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Response To UV Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Response To Radiation DNA Catabolic Process DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Cell Cycle Process Response To Abiotic Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Cell Cycle Checkpoint Cell Cycle Chromosome Organization Aromatic Compound Catabolic Process Pyrimidine Dimer Repair Response To Gamma Radiation Mismatch Repair Cellular Response To Stimulus Immunoglobulin Production Cellular Macromolecule Catabolic Process Response To Light Stimulus Cellular Response To Heat Telomere Maintenance Mitotic Cell Cycle Process Reproduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Organelle Organization Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Response To X-ray Mitotic Recombination
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Intersection) ?