ATR and RAD17

Number of citations of the paper that reports this interaction (PubMedID 31266951)
70

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ATR	RAD17
Description		ATR checkpoint kinase	RAD17 checkpoint clamp loader component
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs		Ceralasertib
Diseases		Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 28957414 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5	20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		545	5884
HPRD ID		08369	09124
Ensembl ID		ENSG00000175054	ENSG00000152942
Uniprot IDs		Q13535	A0A0G2JP78 O75943
PDB IDs		5YZ0	7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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