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ATR and CHD4
Number of citations of the paper that reports this interaction (PubMedID
10545197
)
0
Data Source:
HPRD
(in vivo, in vitro)
ATR
CHD4
Description
ATR checkpoint kinase
chromodomain helicase DNA binding protein 4
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytoskeleton
Membrane
NuRD Complex
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Site Of DNA Damage
Cerebellar Granule Cell To Purkinje Cell Synapse
Molecular Function
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Nucleotide Binding
Transcription Coregulator Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Hydrolase Activity
ATP Hydrolysis Activity
Nucleosomal DNA Binding
Histone Binding
Histone Deacetylase Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
ATP-dependent Chromatin Remodeler Activity
Biological Process
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
Chromatin Organization
Chromatin Remodeling
Negative Regulation Of Gene Expression
Oxygen Transport
Regulation Of Cell Fate Specification
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Regulation Of Synapse Assembly
Terminal Button Organization
Regulation Of Stem Cell Differentiation
Pathways
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
NGF-stimulated transcription
Potential therapeutics for SARS
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Ceralasertib
Diseases
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Myopia (pathological) (
23049088
)
Interacting Genes
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
27 interacting genes:
ATM
ATR
CDR1
CEBPA
EP300
EPAS1
H2AC4
H2BC3
H3-4
H3C1
H4C1
HDAC1
HIF1A
IKZF4
MTNR1A
NCAM2
PSTPIP1
PTEN
RNF8
RORC
SMARCA4
SUMO2
TRIM27
TTN
TWIST1
UBE2I
XRN1
Entrez ID
545
1108
HPRD ID
08369
04472
Ensembl ID
ENSG00000175054
ENSG00000111642
Uniprot IDs
Q13535
A0A2U3TZM0
F5GWX5
Q14839
PDB IDs
5YZ0
1MM2
1MM3
2EE1
2L5U
2L75
2N5N
4O9I
6BGG
6Q3M
6RYR
6RYU
8D4Y
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Chromatin Remodeling
DNA Binding
Chromatin Organization
Protein Localization To Chromosome
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Heterodimerization Activity
Nucleoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Structural Constituent Of Chromatin
Negative Regulation Of Macromolecule Metabolic Process
Chromosome, Telomeric Region
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Transcription Coregulator Binding
Negative Regulation Of Metabolic Process
Chromosome
PML Body
Nucleus
Nucleosome
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Circadian Rhythm
Nucleosome Organization
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Rhythmic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Double-strand Break Repair
SUMO Transferase Activity
Positive Regulation Of Macromolecule Metabolic Process
P53 Binding
Negative Regulation Of RNA Metabolic Process
Histone H2AXS139 Kinase Activity
Negative Regulation Of T Cell Apoptotic Process
Epithelial Cell Maturation
Regulation Of Transcription By RNA Polymerase II
Embryonic Placenta Development
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
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Tagcloud (Intersection)
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