ATR and XRCC5

Number of citations: 0 (PubMedID 15758953)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		ATR	XRCC5
Name		ATR checkpoint kinase	X-ray repair cross complementing 5
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Biosynthetic Process Neurogenesis Regulation Of Telomere Maintenance Small-subunit Processome Assembly Ribosome Biogenesis Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Hematopoietic Stem Cell Proliferation Cellular Response To Gamma Radiation Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor
Pathways		Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs		Ceralasertib	None
Diseases		Alveolar rhabdomyosarcoma Seckel syndrome	None
GWAS		Eosinophil count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 29403010 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 29403010 32888494 ) Red cell distribution width ( 28957414 32888494 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 )	No GWAS studies recorded
Interacting Genes		58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5	59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DEAF1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A
Entrez ID		545	7520
HPRD ID		08369	08935
Ensembl ID		ENSG00000175054	ENSG00000079246
Uniprot IDs		Q13535	P13010
PDB IDs		5YZ0	1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE 7AXZ 7K0Y 7K17 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7SUD 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4
GO Terms Enriched among Interactors		DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	DNA Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Positive Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Telomere Maintenance Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Response To Gamma Radiation Regulation Of RNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Macromolecule Biosynthetic Process Telomere Organization Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Replication Regulation Of Double-strand Break Repair Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Positive Regulation Of DNA-templated Transcription DNA Recombination Negative Regulation Of DNA Metabolic Process DNA Strand Elongation Regulation Of Gene Expression Recombinational Repair Response To Ionizing Radiation