KRT8 and QRSL1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KRT8	QRSL1
Description		keratin 8	glutaminyl-tRNA amidotransferase subunit QRSL1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery	Mitochondrion Glutamyl-tRNA(Gln) Amidotransferase Complex
	Molecular Function	Protein Binding Scaffold Protein Binding	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Ligase Activity Carbon-nitrogen Ligase Activity, With Glutamine As Amido-N-donor Glutaminyl-tRNA Synthase (glutamine-hydrolyzing) Activity
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process	Translation Regulation Of Protein Stability Mitochondrial Translation Glutaminyl-tRNAGln Biosynthesis Via Transamidation
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Tenecteplase Lanoteplase Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)	Clostridioides difficle infection in antibiotics-users ( 33841421) Daytime sleep phenotypes ( 27126917)
Interacting Genes		53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2	3 interacting genes: KRT8 OGT XRCC6
Entrez ID		3856	55278
HPRD ID		01015	15199
Ensembl ID		ENSG00000170421	ENSG00000130348
Uniprot IDs		P05787 Q7L4M3	Q9H0R6
PDB IDs		7K3C 7K3X 7K3Y
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch	Scaffold Protein Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Regulation Of Transcription By Glucose Cellular Response To X-ray Cellular Response To Salt Stress Double-strand Break Repair Via Classical Nonhomologous End Joining NSL Complex Cellular Hyperosmotic Response Regulation Of Phosphorus Metabolic Process Response To Salt Stress Hepatocyte Apoptotic Process Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Protein Modification Process Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Sin3-type Complex Histone Acetyltransferase Complex Telomeric DNA Binding Hyperosmotic Response Response To X-ray Cellular Response To Gamma Radiation Regulation Of Protein Localization To Synapse Negative Regulation Of Stem Cell Population Maintenance Regulation Of Receptor Localization To Synapse ATP-dependent Activity, Acting On DNA Regulation Of Necroptotic Process Cyclin Binding Protein-containing Complex Regulation Of Rac Protein Signal Transduction
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