KRT8 and PIWIL2

Number of citations of the paper that reports this interaction (PubMedID 25113562)
50

Data Source:
BioGRID (pull down)

		KRT8	PIWIL2
Description		keratin 8	piwi like RNA-mediated gene silencing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex
	Molecular Function	Protein Binding Scaffold Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process	Regulation Of Translation Spermatogenesis Cell Differentiation Germ-line Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Negative Regulation Of Circadian Rhythm Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Secondary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated DNA Methylation Positive Regulation Of Cytoplasmic Translation
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	PIWI-interacting RNA (piRNA) biogenesis
Drugs		Tenecteplase Lanoteplase Copper
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)	Hypertriglyceridemia ( 23505323)
Interacting Genes		53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2	5 interacting genes: DDX4 DICER1 KRT8 RNF10 TBCB
Entrez ID		3856	55124
HPRD ID		01015	11434
Ensembl ID		ENSG00000170421	ENSG00000197181
Uniprot IDs		P05787 Q7L4M3	Q8TC59 W0HK13
PDB IDs		7K3C 7K3X 7K3Y	3O7X 3QIR 7YFX
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch	Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulatory RNA Binding Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Helicase Activity Peripheral Nervous System Myelin Formation Negative Regulation Of Nervous System Development Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulatory NcRNA-mediated Gene Silencing Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell Development RISC-loading Complex SiRNA Processing Pi-body Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Tubulin Complex Assembly RISC Complex Assembly SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Transposable Element Silencing By PiRNA-mediated DNA Methylation Pre-miRNA Processing Regulation Of Neurogenesis Myelin Assembly Hepatocyte Apoptotic Process PiRNA Processing P Granule Microtubule Plus-end Binding Regulation Of Nervous System Development Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development MiRNA Metabolic Process
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