ERG and RNF2

Number of citations of the paper that reports this interaction (PubMedID 27626314)
26

Data Source:
BioGRID (pull down)

		ERG	RNF2
Description		ETS transcription factor ERG	ring finger protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Prostate cancer Ewing's sarcoma
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 27386562 31604244) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		99 interacting genes: ACTB ADAR APP ARK2N CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 EXOSC9 FAM218A FBL FLI1 HERC2 HIPK1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 LARS1 MATR3 MNAT1 MSH3 MYO5A NCL NEUROD2 NFIA NFIB NFIC NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PIAS1 PIAS3 POLR2A PRKDC PRPF40A PRPF8 PTPRD PUF60 PVT1 RCC2 RING1 RNF111 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SLX4 SMARCE1 SNRNP200 SOX10 SOX6 SPI1 SPOP STUB1 SYN1 TARBP1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X WDR13 XRN2 ZBED5 ZBTB44 ZMYM2	65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1
Entrez ID		2078	6045
HPRD ID		01298	07028
Ensembl ID		ENSG00000157554	ENSG00000121481
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	Q99496
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG	2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Nucleus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process RNA Processing Ribonucleoprotein Complex Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Processing Regulation Of Primary Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Regulation Of Gene Expression DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Chromatin Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Alternative MRNA Splicing, Via Spliceosome Nuclear Matrix	Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II
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