ERG and TOP2B

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ERG	TOP2B
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	topoisomerase (DNA) II beta 180kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing)
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding DNA Binding, Bending Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change DNA Unwinding Involved In DNA Replication Mitotic Recombination Axonogenesis Forebrain Development Mitotic DNA Integrity Checkpoint
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	14 interactors: CD3E CSNK2B ERG HDAC1 HDAC2 MAPK3 RANBP2 RARA SUMO1 TOP2A TOPBP1 TP53 XPO1 XRCC5
Entrez ID		2078	7155
HPRD ID		01298	00537
Ensembl ID		ENSG00000157554	ENSG00000077097
Uniprot IDs		B4DN83 B4DVX5 P11308	Q02880 Q59H80
PDB IDs		1SXE 4IRG 4IRH 4IRI	3QX3 4G0U 4G0V 4G0W 4J3N
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	Cellular Response To Organic Substance Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Nucleus Cell Differentiation Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Heterocycle Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Metabolic Process Response To Drug Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Fungiform Papilla Formation Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Signaling Fungiform Papilla Morphogenesis Regulation Of Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor Biosynthetic Process Response To Growth Factor Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Fungiform Papilla Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised top2a topoisomerases
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised top2a topoisomerases
Tagcloud (Intersection) ?