ERG and DNAJA2

Number of citations of the paper that reports this interaction (PMID 19940115)
19

Data Source:
BioGRID (pull down)

		ERG	DNAJA2
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	DnaJ (Hsp40) homolog, subfamily A, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Positive Regulation Of Cell Proliferation Response To Heat Protein Refolding
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	2 interactors: ERG HSPA1A
Entrez ID		2078	10294
HPRD ID		01298	07105
Ensembl ID		ENSG00000157554	ENSG00000069345
Uniprot IDs		B4DN83 B4DVX5 P11308	O60884
PDB IDs		1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	Negative Regulation Of Potassium Ion Export Regulation Of Heart Rate By Hormone Cellular Heat Acclimation Regulation Of Heart Rate By Chemical Signal Peptidyl-histidine Phosphorylation Negative Regulation Of Inclusion Body Assembly Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inclusion Body Assembly Protein Refolding Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Regulation Of Cellular Response To Heat Membrane Depolarization During Action Potential Regulation Of Erythrocyte Differentiation Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Negative Regulation Of Ion Transmembrane Transport Cardiac Muscle Contraction Negative Regulation Of Transmembrane Transport Cellular Response To Drug Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Potassium Ion Transport Cellular Response To Heat Heart Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ion Transmembrane Transport Striated Muscle Contraction Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Striated Muscle Contraction Action Potential Protein Stabilization
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnajb1 dnajb4 generate hierarchy hsp105 hsp70 hsp72 hspa1a mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnajb1 dnajb4 generate hierarchy hsp105 hsp70 hsp72 hspa1a mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Intersection) ?