ERG and PUF60

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ERG	PUF60
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	poly-U binding splicing factor 60KDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleoplasm Mitochondrion Golgi Apparatus Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Ribonucleoprotein Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	Nucleotide Binding DNA Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Processing Apoptotic Process RNA Splicing
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	30 interactors: ARL8A CACNA1A CCNC CD101 CHD3 ERG FHL2 FUBP1 HIST1H1C ID3 KIAA0907 KIAA1683 LOH12CR1 MED28 PCBP1 PPP1R16A PTBP2 QRICH1 RAD23B SAP30BP SDCBP SIAH1 SNRPF SRSF11 U2AF2 UBE2I UPF2 VIM YWHAG ZG16
Entrez ID		2078	22827
HPRD ID		01298	18051
Ensembl ID		ENSG00000157554	ENSG00000179950
Uniprot IDs		B4DN83 B4DVX5 P11308	Q9UHX1
PDB IDs		1SXE 4IRG 4IRH 4IRI	2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	RNA Metabolic Process Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA Processing MRNA 3'-end Processing RNA 3'-end Processing Negative Regulation Of RNA Splicing Transcription From RNA Polymerase II Promoter Nuclear Export MRNA Transport RNA Processing Regulation Of Metabolic Process RNA Transport RNA Localization Regulation Of Gene Expression Membrane Depolarization During Action Potential Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Death Negative Regulation Of Muscle Cell Differentiation Cerebellar Molecular Layer Development Negative Regulation Of Potassium Ion Export Positive Regulation Of SUMO Transferase Activity Vestibular Nucleus Development Nucleotide-excision Repair, DNA Damage Recognition Regulation Of Heart Rate By Hormone Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasomal Protein Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Cerebellum Maturation Atrial Cardiac Muscle Cell Development Musculoskeletal Movement, Spinal Reflex Action Regulation Of Apoptotic Process
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	cadherin coding computational consisting decay downregulates enhancer fxr1 fxr2 hnrnp indicates lncrna lncrnas metastasis paired ranging remodelling ribonucleoprotein rnas rnp sf3b3 splicing stimulates suppressing translation translational trerna upregulated utr
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	cadherin coding computational consisting decay downregulates enhancer fxr1 fxr2 hnrnp indicates lncrna lncrnas metastasis paired ranging remodelling ribonucleoprotein rnas rnp sf3b3 splicing stimulates suppressing translation translational trerna upregulated utr
Tagcloud (Intersection) ?