ERG and DDX23

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ERG	DDX23
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm U5 SnRNP Nucleolus Mitochondrion Plasma Membrane Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Cis Assembly Of Pre-catalytic Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	4 interactors: ERG TERF1 TERF2IP WBP4
Entrez ID		2078	9416
HPRD ID		01298	09908
Ensembl ID		ENSG00000157554	ENSG00000174243
Uniprot IDs		B4DN83 B4DVX5 P11308	B3KY11 Q9BUQ8
PDB IDs		1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Heart Rate By Hormone Regulation Of Chromosome Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Homeostatic Process Protection From Non-homologous End Joining At Telomere DNA Replication Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Regulation Of Heart Rate By Chemical Signal Regulation Of Nuclear Cell Cycle DNA Replication Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Negative Regulation Of Telomerase Activity Peptidyl-histidine Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Potassium Ion Export Regulation Of Telomere Maintenance Via Telomerase Cellular Nitrogen Compound Metabolic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Regulation Of Telomerase Activity Phosphorelay Signal Transduction System Response To Drug MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Potassium Ion Transmembrane Transport Nitrogen Compound Metabolic Process Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	arginine assembly associates catalytic complementation destabilizes hela hypophosphorylation immunodepletion integration knock predominantly prp28 ribonucleoprotein rnai rs serine snrnp spliceosomal spliceosome splicing srpk1 srpk2 tri u1 u4 u5 u6 viability
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	arginine assembly associates catalytic complementation destabilizes hela hypophosphorylation immunodepletion integration knock predominantly prp28 ribonucleoprotein rnai rs serine snrnp spliceosomal spliceosome splicing srpk1 srpk2 tri u1 u4 u5 u6 viability
Tagcloud (Intersection) ?