ERG and SNRNP200

Number of citations of the paper that reports this interaction (PubMedID 24591637)
25

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ERG	SNRNP200
Description		ETS transcription factor ERG	small nuclear ribonucleoprotein U5 subunit 200
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Plasma Membrane Cilium Membrane Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases		Prostate cancer Ewing's sarcoma	Retinitis pigmentosa (RP)
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 27386562 31604244) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)
Interacting Genes		99 interacting genes: ACTB ADAR APP ARK2N CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 EXOSC9 FAM218A FBL FLI1 HERC2 HIPK1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 LARS1 MATR3 MNAT1 MSH3 MYO5A NCL NEUROD2 NFIA NFIB NFIC NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PIAS1 PIAS3 POLR2A PRKDC PRPF40A PRPF8 PTPRD PUF60 PVT1 RCC2 RING1 RNF111 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SLX4 SMARCE1 SNRNP200 SOX10 SOX6 SPI1 SPOP STUB1 SYN1 TARBP1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X WDR13 XRN2 ZBED5 ZBTB44 ZMYM2	33 interacting genes: APC BARD1 BCAS2 BRCA1 CEBPA CHMP1B CREBBP DHX38 DUX4 ECT2 ERG GNMT GRB2 HSPB1 LCOR LSM8 MEGF10 PIN1 PRPF3 PRPF31 PRPF6 PTEN RNF10 RNF113A SF3B3 SMNDC1 SUMO2 UBE2I USP19 USP7 VHL YWHAB YWHAG
Entrez ID		2078	23020
HPRD ID		01298	03391
Ensembl ID		ENSG00000157554	ENSG00000144028
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	O75643
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG	2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS1 7OS2 7PX3 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8BCH 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP9 8QPA 8QPB 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O 9FMD
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Nucleus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process RNA Processing Ribonucleoprotein Complex Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Processing Regulation Of Primary Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Regulation Of Gene Expression DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Chromatin Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Alternative MRNA Splicing, Via Spliceosome Nuclear Matrix	Nucleoplasm Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing Post-translational Protein Modification Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Protein Modification Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Primary Metabolic Process Nuclear Speck MRNA Metabolic Process RNA Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein Modification By Small Protein Conjugation Spliceosomal Tri-snRNP Complex Assembly Protein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Stability Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Protein Kinase C Inhibitor Activity Cellular Response To Ionizing Radiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein K6-linked Ubiquitination Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Regulation Of Cell Cycle BRCA1-B Complex Postsynaptic Cytosol U2-type Spliceosomal Complex RNA Processing Catalytic Step 2 Spliceosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?