ERG and RCC2

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ERG	RCC2
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	regulator of chromosome condensation 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleolus Cytosol Microtubule Midbody Chromosome, Centromeric Core Domain Mitotic Spindle Midzone
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	Protein Binding Microtubule Binding Poly(A) RNA Binding Rac GTPase Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Mitotic Cell Cycle Endosome Organization Mitotic Nuclear Division Integrin-mediated Signaling Pathway Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Migration Negative Regulation Of GTPase Activity Focal Adhesion Assembly Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Passenger Complex Localization To Kinetochore Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)	Basal cell carcinoma ( 18849993)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	3 interactors: ERG PRPF40A RAC1
Entrez ID		2078	55920
HPRD ID		01298	18171
Ensembl ID		ENSG00000157554	ENSG00000179051
Uniprot IDs		B4DN83 B4DVX5 P11308	Q9P258
PDB IDs		1SXE 4IRG 4IRH 4IRI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	Negative Regulation Of Potassium Ion Export Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Regulation Of Heart Rate By Hormone Engulfment Of Apoptotic Cell Mast Cell Chemotaxis Negative Regulation Of Transport Regulation Of Actin Filament-based Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb Olfactory Bulb Interneuron Development Regulation Of Heart Rate By Chemical Signal Regulation Of Cell Morphogenesis Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Regulation Of Hydrogen Peroxide Metabolic Process Potassium Ion Export Regulation Of Respiratory Burst Auditory Receptor Cell Morphogenesis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Phagocytosis, Engulfment Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Olfactory Bulb Interneuron Differentiation Positive Regulation Of Lamellipodium Assembly Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Auditory Receptor Cell Development Dopaminergic Neuron Differentiation Membrane Invagination Positive Regulation Of Lamellipodium Organization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Cellular Component Movement Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Arrangement Cell Proliferation Regulation Of Membrane Repolarization Ruffle Assembly Negative Regulation Of Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Hyperosmotic Response Positive Regulation Of Neutrophil Chemotaxis Regulation Of Lamellipodium Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Defense Response To Virus By Virus Positive Regulation Of Adherens Junction Organization Cochlea Morphogenesis Positive Regulation Of Granulocyte Chemotaxis
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	29c actually advantage agar ascertain brdu carcinoma cdk6 confer downregulated downregulation gastric harbored incorporation microarray mir mirna mkn45 mkn7 mkn74 partly ppic s10 sirnas suppression suppressive transfected utr verified
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	29c actually advantage agar ascertain brdu carcinoma cdk6 confer downregulated downregulation gastric harbored incorporation microarray mir mirna mkn45 mkn7 mkn74 partly ppic s10 sirnas suppression suppressive transfected utr verified
Tagcloud (Intersection) ?