ERG and HERC2

Number of citations of the paper that reports this interaction (PubMedID 27626314)
26

Data Source:
BioGRID (pull down)

		ERG	HERC2
Description		ETS transcription factor ERG	HECT and RLD domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	DNA Repair Intracellular Protein Transport DNA Damage Response Spermatogenesis Protein Ubiquitination Neuron Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Prostate cancer Ewing's sarcoma
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 27386562 31604244) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Adiponectin levels ( 33562295) Age-related macular degeneration ( 32741009) Asthma and eczema ( 34155719) Basal cell carcinoma ( 31174203) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Bone mineral content ( 31790847) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Colorectal cancer ( 29228715) Corneal astigmatism ( 30306274) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Diisocyanate-induced asthma ( 25918132) Eye color ( 23548203 30664655 23118974) Eye color (brightness) ( 30664655) Eye color (hue) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 20463881 30166351) Hair color ( 26926045 29662168 23548203 30664655) Hair morphology traits ( 30166351) Intraocular pressure ( 31959993) Iris color ( 18252221) Iris color (b* coordinate) ( 30895295) Iris color (L* coordinate) ( 30895295) Iris heterochromicity ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Monobrow ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Perceived skin darkness ( 25963972) Red vs. brown/black hair color ( 30531825) Refractive astigmatism ( 30306274) Rosacea symptom severity ( 29771307) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Tanning ( 23548203) Type 2 diabetes ( 32499647) Uveal melanoma ( 28781888) Vitiligo ( 22561518 27723757)
Interacting Genes		99 interacting genes: ACTB ADAR APP ARK2N CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 EXOSC9 FAM218A FBL FLI1 HERC2 HIPK1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 LARS1 MATR3 MNAT1 MSH3 MYO5A NCL NEUROD2 NFIA NFIB NFIC NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PIAS1 PIAS3 POLR2A PRKDC PRPF40A PRPF8 PTPRD PUF60 PVT1 RCC2 RING1 RNF111 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SLX4 SMARCE1 SNRNP200 SOX10 SOX6 SPI1 SPOP STUB1 SYN1 TARBP1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X WDR13 XRN2 ZBED5 ZBTB44 ZMYM2	15 interacting genes: BDKRB2 C5AR2 CALM1 CDC42 ERG PDE9A RNF11 STK11 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2L3 UBE2N XPA
Entrez ID		2078	8924
HPRD ID		01298	06905
Ensembl ID		ENSG00000157554	ENSG00000128731
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	A8KAQ8 O95714
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG	2KEO 3KCI 4L1M 6WW3 6WW4 7Q40 7Q41 7Q42 7Q43 7Q44 7Q45 7Q46 7RGW
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Nucleus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process RNA Processing Ribonucleoprotein Complex Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Processing Regulation Of Primary Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Regulation Of Gene Expression DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Chromatin Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Alternative MRNA Splicing, Via Spliceosome Nuclear Matrix	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Post-translational Protein Modification Catabolic Process Macromolecule Catabolic Process Negative Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activator Activity Proteolysis Protein Autoubiquitination Nucleoplasm Golgi Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Cytosol Positive Regulation Of Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Nucleotide Binding Transferase Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of Protein Targeting To Mitochondrion Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Substantia Nigra Development Regulation Of Protein Targeting To Mitochondrion ATP Binding Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Nucleotide-excision Repair, DNA Damage Recognition
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