ERG and SLX4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ERG	SLX4
Description		ETS transcription factor ERG	SLX4 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways			Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases		Prostate cancer Ewing's sarcoma
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 27386562 31604244) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Type 2 diabetes ( 32499647)
Interacting Genes		99 interacting genes: ACTB ADAR APP ARK2N CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 EXOSC9 FAM218A FBL FLI1 HERC2 HIPK1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 JUN LANCL1 LARS1 MATR3 MNAT1 MSH3 MYO5A NCL NEUROD2 NFIA NFIB NFIC NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PIAS1 PIAS3 POLR2A PRKDC PRPF40A PRPF8 PTPRD PUF60 PVT1 RCC2 RING1 RNF111 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SLX4 SMARCE1 SNRNP200 SOX10 SOX6 SPI1 SPOP STUB1 SYN1 TARBP1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X WDR13 XRN2 ZBED5 ZBTB44 ZMYM2	9 interacting genes: APP EME1 ERCC4 ERG MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		2078	84464
HPRD ID		01298	12537
Ensembl ID		ENSG00000157554	ENSG00000188827
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	Q8IY92
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG	4M7C 4UYI 4ZOU 7BU5 7TUJ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Nucleus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process RNA Processing Ribonucleoprotein Complex Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Processing Regulation Of Primary Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Regulation Of Gene Expression DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Chromatin Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Alternative MRNA Splicing, Via Spliceosome Nuclear Matrix	Crossover Junction DNA Endonuclease Activity Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Nuclease Activity Telomere Organization Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Resolution Of Mitotic Recombination Intermediates Double-strand Break Repair Response To DNA Damage Checkpoint Signaling DNA Recombination Meiosis I Cell Cycle Process Endonuclease Activity Resolution Of DNA Recombination Intermediates Nucleoplasm Chromosome Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleus Nuclear Replication Fork Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Endonuclease Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Mitotic Cell Cycle DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Replication Fork Processing Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Maintenance Via Telomere Lengthening DNA Binding Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Chaperone-mediated Autophagy DNA Metabolic Process SUMO Conjugating Enzyme Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle
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