ERG and ADAR

Number of citations of the paper that reports this interaction (PMID 24591637)
2

Data Source:
BioGRID (pull down)

		ERG	ADAR
Gene Name		v-ets avian erythroblastosis virus E26 oncogene homolog	adenosine deaminase, RNA-specific
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Signal Transducer Activity Protein Binding Sequence-specific DNA Binding	DNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Multicellular Organismal Development Cell Proliferation Cell Differentiation	Osteoblast Differentiation In Utero Embryonic Development Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Response To Virus Gene Expression Base Conversion Or Substitution Editing MRNA Modification Cytokine-mediated Signaling Pathway Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Negative Regulation Of RNA Interference
Pathways			Formation of editosomes by ADAR proteins Interferon Signaling Cytokine Signaling in Immune system mRNA Editing: A to I Conversion C6 deamination of adenosine Interferon alpha/beta signaling mRNA Editing
Drugs
Diseases
GWAS		Metabolite levels (HVA) ( 23319000) Neonatal lupus ( 20662065) White blood cell types ( 21738478)	Prostate cancer ( 23535732)
Protein-Protein Interactions		61 interactors: ACTB ADAR APP CDC5L CLTC DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 FBL FLI1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 ILF2 ILF3 JUN LANCL1 MATR3 NCL NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 POLR2A PRKDC PRPF40A PRPF8 PUF60 RCC2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SNRNP200 SPI1 SYN1 TOP1 TOP2B USP9X XRN2	5 interactors: ERG HDLBP TGM2 UBE2I XPO1
Entrez ID		2078	103
HPRD ID		01298	07528
Ensembl ID		ENSG00000157554	ENSG00000160710
Uniprot IDs		B4DN83 B4DVX5 P11308	P55265
PDB IDs		1SXE 4IRG 4IRH 4IRI	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 3F21 3F22 3F23 3IRQ 3IRR
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Metabolic Process Osteoblast Differentiation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Protein Refolding Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribosome Biogenesis Chromosome Organization Ossification Cis Assembly Of Pre-catalytic Spliceosome DNA Metabolic Process Regulation Of MRNA Stability Cell Differentiation Rhythmic Process Developmental Process Regulation Of RNA Stability Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process MRNA Stabilization Negative Regulation Of Transcription, DNA-templated Circadian Rhythm Ribonucleoprotein Complex Assembly	Negative Regulation Of Potassium Ion Export Positive Regulation Of SUMO Transferase Activity Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Heart Rate By Hormone Ribosomal Small Subunit Export From Nucleus Peptidyl-amino Acid Modification Peptidyl-lysine Modification Salivary Gland Cavitation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ribosomal Subunit Export From Nucleus Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Peptidyl-histidine Phosphorylation Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Phosphorelay Signal Transduction System Positive Regulation Of Potassium Ion Transmembrane Transport Metal Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Cell Action Potential Response To Drug Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Viral Process Ion Homeostasis Regulation Of Protein Export From Nucleus Protein Sumoylation Intracellular Transport Of Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Branching Involved In Salivary Gland Morphogenesis Apoptotic Cell Clearance Protein Export From Nucleus Endoplasmic Reticulum Calcium Ion Homeostasis Membrane Depolarization During Action Potential Regulation Of Centrosome Duplication Cardiac Muscle Cell Action Potential Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Centrosome Cycle
Tagcloud ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1
Tagcloud (Difference) ?		antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed	adar2 adars adenosines azan azanebularine biophysical deaminase deaminases deaminate deaminated deeper deoxy dsrbd dsrbds duplex edited editing emsa footprinting hadar2 hydrolytically mechanistically misregulation modular nt nucleoside positioning ribonuclease v1
Tagcloud (Intersection) ?