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SREK1 and NPM1
Number of citations of the paper that reports this interaction (PMID
14559993
)
9
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
SREK1
NPM1
Gene Name
splicing regulatory glutamine/lysine-rich protein 1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Spliceosomal Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Membrane
Ribonucleoprotein Complex
Spindle Pole Centrosome
Molecular Function
Nucleotide Binding
Poly(A) RNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Tat Protein Binding
Histone Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
Poly(A) RNA Binding
Protein Heterodimerization Activity
NF-kappaB Binding
Unfolded Protein Binding
Biological Process
MRNA Processing
RNA Splicing
DNA Repair
Nucleosome Assembly
Intracellular Protein Transport
Nucleocytoplasmic Transport
Response To Stress
Centrosome Cycle
Signal Transduction
Cell Aging
Protein Localization
Negative Regulation Of Cell Proliferation
Negative Regulation Of Centrosome Duplication
Viral Process
Regulation Of Endodeoxyribonuclease Activity
CENP-A Containing Nucleosome Assembly
Ribosome Assembly
Negative Regulation Of Apoptotic Process
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Regulation Of Centriole Replication
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Oligomerization
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Pathways
Chromosome Maintenance
Nucleosome assembly
HIV Infection
Nuclear import of Rev protein
Deposition of new CENPA-containing nucleosomes at the centromere
Host Interactions of HIV factors
Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
55 interactors:
CD8A
CSNK2A1
DDX17
DDX39B
DDX3X
DGKA
DGKD
EFTUD2
ELAVL1
GNB2L1
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPC
HNRNPD
HNRNPH1
HNRNPK
HNRNPU
ILF2
MDM2
NCL
NPM1
PABPC1
PABPC4
PARP1
PIN1
RBM10
RBMX
SAFB
SF3A3
SF3B3
SFPQ
SH3GLB2
SNRPD1
SNRPD3
SRPK1
SRPK2
SRPK3
SRSF1
SRSF10
SRSF11
SRSF2
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
SSRP1
SUPT16H
TARBP1
THRAP3
TRA2B
YBX1
ZRANB2
53 interactors:
ABCC1
ACY1
ALK
APP
ARF1
CDK1
CDK2
CDKN1A
CDT1
COX8A
CSNK2A1
EIF2AK2
EIF3E
ELF4
EP300
ERG
GADD45A
GNAI2
GRB2
GZMM
HAND2
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST3H3
HMGA1
HMGA2
HOXA7
IRF1
IRS1
MDM2
NCL
NOP2
NPM2
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SREK1
TCERG1
TFAP2A
TP53
UQCRH
USP36
XPO1
YY1
Entrez ID
140890
4869
HPRD ID
18043
01246
Ensembl ID
ENSG00000153914
ENSG00000181163
Uniprot IDs
E5RFV3
Q8WXA9
P06748
PDB IDs
2LLH
2P1B
2VXD
Enriched GO Terms of Interacting Partners
?
RNA Splicing
RNA Processing
MRNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
MRNA Metabolic Process
Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of MRNA Processing
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of RNA Splicing
RNA Export From Nucleus
Termination Of RNA Polymerase II Transcription
RNA Transport
MRNA Export From Nucleus
RNA Localization
MRNA 3'-end Processing
Nuclear Export
MRNA Transport
Cellular Metabolic Process
RNA 3'-end Processing
DNA-templated Transcription, Termination
Ribonucleoprotein Complex Assembly
Regulation Of MRNA Stability
Regulation Of RNA Stability
Nucleocytoplasmic Transport
Nuclear Transport
Spliceosomal Complex Assembly
Regulation Of Gene Expression
Negative Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of RNA Splicing
MRNA Stabilization
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Metabolic Process
Ribonucleoprotein Complex Biogenesis
Transcription, DNA-templated
Posttranscriptional Regulation Of Gene Expression
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Cytoplasmic Transport
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Innate Immune Response
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Cell Cycle
Cell Cycle Checkpoint
Mitotic Cell Cycle Checkpoint
Regulation Of Gene Expression
Immune System Process
Response To Stress
Regulation Of Cell Cycle Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Immune Response
Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Biosynthetic Process
Mitotic DNA Damage Checkpoint
DNA Damage Checkpoint
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Mitotic DNA Integrity Checkpoint
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Cell Cycle
Chromosome Organization
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Protein Metabolic Process
Nitrogen Compound Metabolic Process
Mitotic Cell Cycle
Regulation Of Transcription, DNA-templated
DNA Packaging
Nucleobase-containing Compound Metabolic Process
Fc Receptor Signaling Pathway
Regulation Of Cell Proliferation
Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Cellular Nitrogen Compound Metabolic Process
Tagcloud
?
aggressive
aml
amplicon
consecutive
counterparts
covering
de
expands
flt3
frequent
heterogeneous
hotspots
illumina
mds
mutated
myeloid
neoplasms
next
novo
panel
prevalent
profile
profiling
ptpn11
similarly
summary
syndromes
tp53
truseq
Tagcloud (Difference)
?
aggressive
aml
amplicon
consecutive
counterparts
covering
de
expands
flt3
frequent
heterogeneous
hotspots
illumina
mds
mutated
myeloid
neoplasms
next
novo
panel
prevalent
profile
profiling
ptpn11
similarly
summary
syndromes
tp53
truseq
Tagcloud (Intersection)
?