SREK1 and DDX3X

Number of citations of the paper that reports this interaction (PMID 14559993)
9

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SREK1	DDX3X
Gene Name		splicing regulatory glutamine/lysine-rich protein 1	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex	Nucleus Cytoplasm Mitochondrial Outer Membrane Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Nuclear Speck Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Poly(A) RNA Binding	DNA Binding RNA Binding GTPase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding ATPase Activity Nucleoside-triphosphatase Activity Translation Initiation Factor Binding RNA Stem-loop Binding Ribosomal Small Subunit Binding CTPase Activity Poly(A) RNA Binding MRNA 5'-UTR Binding
	Biological Process	MRNA Processing RNA Splicing	Transcription, DNA-templated Chromosome Segregation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein Complex Assembly DNA Duplex Unwinding Positive Regulation Of Interferon-beta Production Stress Granule Assembly Intracellular Signal Transduction Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		55 interactors: CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GNB2L1 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 RBM10 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B YBX1 ZRANB2	12 interactors: APBB1 CSNK2A1 IL7R NEDD4 NFKB2 NUP62 PIN1 SREK1 WBP4 XPO1 YWHAQ ZNF512B
Entrez ID		140890	1654
HPRD ID		18043	02154
Ensembl ID		ENSG00000153914	ENSG00000215301
Uniprot IDs		E5RFV3 Q8WXA9	O00571
PDB IDs			2I4I 2JGN 3JRV
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Export From Nucleus Termination Of RNA Polymerase II Transcription RNA Transport MRNA Export From Nucleus RNA Localization MRNA 3'-end Processing Nuclear Export MRNA Transport Cellular Metabolic Process RNA 3'-end Processing DNA-templated Transcription, Termination Ribonucleoprotein Complex Assembly Regulation Of MRNA Stability Regulation Of RNA Stability Nucleocytoplasmic Transport Nuclear Transport Spliceosomal Complex Assembly Regulation Of Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing MRNA Stabilization Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Cytoplasmic Transport Positive Regulation Of Cellular Biosynthetic Process	Response To Cytokine Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cytokine-mediated Signaling Pathway Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Cellular Component Organization Signaling Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Cycle Regulation Of Protein Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Thymidylate Synthase Biosynthetic Process Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Follicular Dendritic Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Cell Death Death Cellular Response To Organic Substance Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Process MRNA Transport Regulation Of Mitotic Nuclear Division Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically
Tagcloud (Difference) ?			aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically
Tagcloud (Intersection) ?