NPM1 and ALK

Number of citations of the paper that reports this interaction (PMID 11888936)
27

Data Source:
HPRD (in vitro, in vivo)

		NPM1	ALK
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	anaplastic lymphoma receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Integral Component Of Plasma Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Phosphorylation Peptidyl-tyrosine Phosphorylation NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Protein Autophosphorylation Neuron Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	13 interactors: IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		4869	238
HPRD ID		01246	00104
Ensembl ID		ENSG00000181163	ENSG00000171094
Uniprot IDs		P06748	B6D4Y2 Q9UM73
PDB IDs		2LLH 2P1B 2VXD	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Growth Hormone Receptor Signaling Pathway Signaling Cellular Response To Growth Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Cellular Response To Stimulus Defense Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Hormone Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Organonitrogen Compound Regulation Of Apoptotic Process Response To Peptide Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Cell Death Negative Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Learning Or Memory Positive Regulation Of Metabolic Process Response To Growth Factor Response To Organic Substance Cognition Response To Insulin
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve
Tagcloud (Intersection) ?