NPM1 and PSMC4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NPM1	PSMC4
Description		nucleophosmin 1	proteasome 26S subunit, ATPase 4
Image
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Ciliary Basal Body
	Molecular Function	Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling Protein Import Into Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Macrophage Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Regulation Of Cell Population Proliferation Ribosome Biogenesis Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Senescence Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Blastocyst Development Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SARS-CoV-1-host interactions ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer PKR-mediated signaling	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Artenimol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		68 interacting genes: ABCC1 ACY1 ALK APP ARF1 ATM CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CHEK1 CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 GADD45A GGA1 GGA2 GGA3 GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NIBAN1 NOP2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIRT7 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 UBC UQCRH WEE2-AS1 XPO1 YY1	17 interacting genes: CEBPA FILNC1 NPM1 NR1I3 OGT PAAF1 PSMC2 PSMC3 PSMC5 PSMD10 RNF2 RORB SUMO2 TRAP1 UBASH3A UBLCP1 ZFAND1
Entrez ID		4869	5704
HPRD ID		01246	04085
Ensembl ID		ENSG00000181163	ENSG00000013275
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 E5RI98 P06748	A8K2M0 P43686
PDB IDs		2LLH 2P1B 2VXD 5EHD 7OBG 7OBH 8AH2 8AS5	2DVW 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Response To Stress Protein Localization To Organelle Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Chromatin Binding Protein Localization To Site Of Double-strand Break Negative Regulation Of DNA Metabolic Process	Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Complex Proteasome-activating Activity Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Proteasome Accessory Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ATP Hydrolysis Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA
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