SREK1 and NAT10

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SREK1	NAT10
Description		splicing regulatory glutamic acid and lysine rich protein 1	N-acetyltransferase 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane Midbody Small-subunit Processome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	TRNA Binding Nucleotide Binding RNA Binding Protein Binding ATP Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups TRNA Cytidine N4-acetyltransferase Activity DNA Polymerase Binding MRNA N-acetyltransferase Activity 18S RRNA Cytidine N-acetyltransferase Activity
	Biological Process	MRNA Processing RNA Splicing	RRNA Modification TRNA Wobble Cytosine Modification RRNA Processing Regulation Of Translation Protein Acetylation TRNA Processing RNA Modification Regulation Of Centrosome Duplication RRNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Translation TRNA Acetylation RRNA Acetylation Involved In Maturation Of SSU-rRNA
Pathways			rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Metabolite levels ( 23823483)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	11 interacting genes: CD2BP2 CENATAC MDM2 PARP1 SREK1 SUMO2 TP53 UBC UBE2D2 UBE2I USP7
Entrez ID		140890	55226
HPRD ID		18043	10964
Ensembl ID		ENSG00000153914	ENSG00000135372
Uniprot IDs		Q8WXA9	Q9H0A0
PDB IDs			6VLA 7MQ8 7MQ9
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Post-translational Protein Modification SUMO Transferase Activity PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Cellular Response To Actinomycin D Protein Modification By Small Protein Conjugation Nuclear Body Response To Actinomycin D Nucleoplasm Cellular Response To UV-C Response To Gamma Radiation Protein Sumoylation Mitochondrial DNA Repair P53 Binding Protein Modification Process Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Cellular Response To UV Cellular Response To Light Stimulus Regulation Of Telomere Maintenance Proteolysis Response To UV-C Protein Tag Activity Regulation Of Circadian Rhythm Negative Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Mitochondrial DNA Metabolic Process Protein-containing Complex Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Response To Ionizing Radiation Negative Regulation Of Proteolysis Response To UV Disordered Domain Specific Binding Cellular Response To Gamma Radiation Presynaptic Cytosol Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Radiation Postsynaptic Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of Programmed Necrotic Cell Death Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
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