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NPM1 and H2BC21
Number of citations of the paper that reports this interaction (PubMedID
16107701
)
67
Data Source:
BioGRID
(affinity chromatography technology, pull down)
NPM1
H2BC21
Description
nucleophosmin 1
H2B clustered histone 21
Image
GO Annotations
Cellular Component
Granular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Focal Adhesion
Large Ribosomal Subunit
Small Ribosomal Subunit
Membrane
Nuclear Speck
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytosol
Extracellular Exosome
Molecular Function
Core Promoter Sequence-specific DNA Binding
Nucleic Acid Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
RRNA Binding
Protein Kinase Binding
Tat Protein Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
NF-kappaB Binding
Unfolded Protein Binding
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Biological Process
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Regulation Of Cell Growth
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
Protein Import Into Nucleus
Cell Volume Homeostasis
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Intracellular Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Macrophage Differentiation
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Endodeoxyribonuclease Activity
Cellular Response To UV
Regulation Of Cell Population Proliferation
Ribosome Biogenesis
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Negative Regulation Of MRNA Splicing, Via Spliceosome
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Cellular Senescence
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Protein Localization To Nucleolus
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Bacterium
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SARS-CoV-1-host interactions
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
PKR-mediated signaling
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Artenimol
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Multisite chronic pain (
33830993
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
68 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
ATM
CACYBP
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CHEK1
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
GADD45A
GGA1
GGA2
GGA3
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NIBAN1
NOP2
OGT
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SIRT7
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
UBC
UQCRH
WEE2-AS1
XPO1
YY1
73 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NEIL3
NPM1
PARP10
PARP9
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMU1
SPANXN2
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
Entrez ID
4869
8349
HPRD ID
01246
03494
Ensembl ID
ENSG00000181163
ENSG00000184678
Uniprot IDs
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
E5RI98
P06748
Q16778
PDB IDs
2LLH
2P1B
2VXD
5EHD
7OBG
7OBH
8AH2
8AS5
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
7BXT
7EA8
7U0G
7U0I
7U0J
8DK5
8EVG
8EVH
8EVI
8EVJ
8H1T
8SPS
8SPU
8SYP
8UQ8
8UQ9
8UQA
8UQB
8UQC
8UQD
8UQE
8YJF
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Signal Transduction In Response To DNA Damage
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Protein Catabolic Process
Response To Stress
Protein Localization To Organelle
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Gene Expression
Cellular Response To Oxygen-containing Compound
Chromatin Binding
Protein Localization To Site Of Double-strand Break
Negative Regulation Of DNA Metabolic Process
Chromatin Organization
Chromatin Remodeling
Histone Binding
Nucleoplasm
Nucleus
Protein Modification Process
Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Cellular Response To Stress
Post-translational Protein Modification
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Negative Regulation Of Macromolecule Metabolic Process
Transferase Activity
Nucleic Acid Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Epigenetic Regulation Of Gene Expression
Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Coactivator Activity
Regulation Of Signal Transduction By P53 Class Mediator
Histone H3K18 Acetyltransferase Activity
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