SREK1 and GPRASP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SREK1	GPRASP2
Description		splicing regulatory glutamic acid and lysine rich protein 1	G protein-coupled receptor associated sorting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding
	Biological Process	MRNA Processing RNA Splicing	Hematopoietic Stem Cell Homeostasis
Pathways
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688
Entrez ID		140890	114928
HPRD ID		18043	06612
Ensembl ID		ENSG00000153914	ENSG00000158301
Uniprot IDs		Q8WXA9	B3KW05 Q96D09
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite
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