NPM1 and PLK1

  • Number of citations of the paper that reports this interaction (PMID 15190079)
  • 21
  • Data Source:
  • HPRD (in vivo, in vitro)

NPM1

PLK1

Gene Name nucleophosmin (nucleolar phosphoprotein B23, numatrin) polo-like kinase 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1 99 interactors: ACTL6B APP ASPM BAG6 BIRC6 BRCA2 BUB1 C6orf136 C9orf114 CCDC115 CCNB1 CDC20 CDC25C CENPQ CENPU CEP55 CHEK2 CIC CPSF3L CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FLJ20712 FZR1 GET4 GLB1 GORASP1 HSF1 IKBKB ITSN1 KIF23 KLHL22 KRBA1 LMO4 LRP5L MAGED1 MAPK6 MCM2 MCM3 MCM7 MDM2 MPP2 MYT1 NEDD4 NINL NPM1 NUDC OFD1 PHC2 PIN1 PITPNM1 PKMYT1 PPID PRC1 PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RABAC1 RAP1GAP RBX1 RECQL5 RELA RNF126 RXRA SIMC1 SNCA SNCB STAG2 SUGT1 TANK TNFSF11 TP53 TP53BP1 TP53BP2 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 VRK3 WEE1 ZNF71
Entrez ID 4869 5347
HPRD ID 01246 03652
Ensembl ID ENSG00000181163 ENSG00000166851
Uniprot IDs P06748 P53350
PDB IDs 2LLH 2P1B 2VXD 1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53
Enriched GO Terms of Interacting Partners?
Tagcloud ?
aggressive  aml  amplicon  consecutive  counterparts  covering  de  expands  flt3  frequent  heterogeneous  hotspots  illumina  mds  mutated  myeloid  neoplasms  next  novo  panel  prevalent  profile  profiling  ptpn11  similarly  summary  syndromes  tp53  truseq 
53bp1  atm  brca1  cdk1  comparatively  coordinates  cytosol  ddr  enables  exit  flanking  genotoxic  h2a  homologous  impairs  interphase  joining  kinetochores  ligases  localize  mitosis  mitotic  properly  recombination  rnf168  rnf8  s1618  spatiotemporally  ubiquitinated 
Tagcloud (Difference) ?
aggressive  aml  amplicon  consecutive  counterparts  covering  de  expands  flt3  frequent  heterogeneous  hotspots  illumina  mds  mutated  myeloid  neoplasms  next  novo  panel  prevalent  profile  profiling  ptpn11  similarly  summary  syndromes  tp53  truseq 
53bp1  atm  brca1  cdk1  comparatively  coordinates  cytosol  ddr  enables  exit  flanking  genotoxic  h2a  homologous  impairs  interphase  joining  kinetochores  ligases  localize  mitosis  mitotic  properly  recombination  rnf168  rnf8  s1618  spatiotemporally  ubiquitinated 
Tagcloud (Intersection) ?