NPM1 and GZMM

Number of citations of the paper that reports this interaction (PMID 19103589)
6

Data Source:
BioGRID (enzymatic study)

		NPM1	GZMM
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	granzyme M (lymphocyte met-ase 1)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Extracellular Region Membrane
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Proteolysis Apoptotic Process Cytolysis Innate Immune Response
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins	Alternative complement activation Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	5 interactors: DFFA EZR NPM1 PARP1 TUBA1B
Entrez ID		4869	3004
HPRD ID		01246	02633
Ensembl ID		ENSG00000181163	ENSG00000197540
Uniprot IDs		P06748	P51124
PDB IDs		2LLH 2P1B 2VXD	1LZP 2ZGC 2ZGH 2ZGJ 2ZKS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Negative Regulation Of Apoptotic DNA Fragmentation Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Growth Rate Protein Poly-ADP-ribosylation Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity DNA Metabolic Process Membrane To Membrane Docking Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Apoptotic DNA Fragmentation DNA Damage Response, Detection Of DNA Damage Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Transcription Regulatory Region DNA Binding Protein Autoprocessing Cytoskeletal Anchoring At Plasma Membrane Regulation Of Centriole Replication Positive Regulation Of Gene Expression Positive Regulation Of SMAD Protein Import Into Nucleus Microvillus Assembly Microvillus Organization Negative Regulation Of Centrosome Duplication Microtubule Cytoskeleton Organization Regulation Of SMAD Protein Import Into Nucleus T Cell Apoptotic Process Filopodium Assembly Apoptotic DNA Fragmentation Macrophage Differentiation Cellular Response To Organic Substance Cellular Component Assembly Cellular Response To Superoxide Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Execution Phase Of Apoptosis CENP-A Containing Nucleosome Assembly Response To Superoxide Protein ADP-ribosylation Response To Oxygen Radical Establishment Of Endothelial Barrier Negative Regulation Of Cellular Metabolic Process DNA Repair Ribosome Assembly Apoptotic Nuclear Changes Cellular Macromolecular Complex Assembly Histone Exchange Signal Transduction Involved In Regulation Of Gene Expression
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Intersection) ?