NPM1 and IRS1

Number of citations of the paper that reports this interaction (PubMedID 8633037)
36

Data Source:
HPRD (in vitro)

		NPM1	IRS1
Description		nucleophosmin 1	insulin receptor substrate 1
Image
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Intracellular Membrane-bounded Organelle
	Molecular Function	Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Signaling Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling Protein Import Into Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Macrophage Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Regulation Of Cell Population Proliferation Ribosome Biogenesis Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Senescence Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Glucose Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Fatty Acid
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SARS-CoV-1-host interactions ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer PKR-mediated signaling	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling Signaling by LTK
Drugs		Artenimol	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)	Adiponectin levels ( 22479202 31178129) Adiposity ( 21706003) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 28724990 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Birth weight ( 31043758) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 28270201 26833246) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) Glucose homeostasis traits ( 25524916) HDL cholesterol ( 25961943 20686565 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Lean body mass ( 28724990) Leg fat mass (lean adjusted) ( 32719433) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Metabolite levels ( 23823483) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Problematic alcohol use ( 32451486) Sexual dimorphism in anthropometric traits ( 23754948) Spleen volume ( 34128465) Triglyceride levels ( 28334899 32203549) Triglycerides ( 25961943 24097068 20686565) Type 2 diabetes ( 20581827 31118516 30297969 29358691 24509480 22885922 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		68 interacting genes: ABCC1 ACY1 ALK APP ARF1 ATM CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CHEK1 CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 GADD45A GGA1 GGA2 GGA3 GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NIBAN1 NOP2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIRT7 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 UBC UQCRH WEE2-AS1 XPO1 YY1	81 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 NUMB PASK PDPK1 PELI1 PELI2 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TRAF4 TRIM72 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		4869	3667
HPRD ID		01246	00943
Ensembl ID		ENSG00000181163	ENSG00000169047
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 E5RI98 P06748	P35568
PDB IDs		2LLH 2P1B 2VXD 5EHD 7OBG 7OBH 8AH2 8AS5	1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT 7PPL 7PPM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Response To Stress Protein Localization To Organelle Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Chromatin Binding Protein Localization To Site Of Double-strand Break Negative Regulation Of DNA Metabolic Process	Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Phosphorylation Protein Kinase Activity Phosphorylation Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Regulation Of Immune Response Regulation Of Cellular Component Organization Phosphate-containing Compound Metabolic Process Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Response To Stress Negative Regulation Of Signal Transduction ATP Binding Regulation Of Immune System Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Multicellular Organismal Process Phosphotyrosine Residue Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Transferase Activity Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Stress Intracellular Signaling Cassette Positive Regulation Of Immune System Process Positive Regulation Of Metabolic Process Cellular Response To Oxygen-containing Compound
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