SREK1 and THRAP3

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SREK1	THRAP3
Description		splicing regulatory glutamic acid and lysine rich protein 1	thyroid hormone receptor associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Nucleoplasm Mediator Complex Nuclear Speck Exon-exon Junction Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding ATP Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Phosphoprotein Binding
	Biological Process	MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing Circadian Rhythm RNA Splicing Positive Regulation Of Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Rhythmic Process
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	13 interacting genes: APBB1 CEBPA CLK1 CSNK2A1 NEDD4 OGT PIN1 RNF10 SHANK3 SREK1 USP7 WEE2-AS1 YWHAG
Entrez ID		140890	9967
HPRD ID		18043	07543
Ensembl ID		ENSG00000153914	ENSG00000054118
Uniprot IDs		Q8WXA9	Q9Y2W1
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of Protein Catabolic Process Protein Localization To Vacuole Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Phosphothreonine Residue Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphoserine Residue Binding Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Lysosome TORC1 Signaling Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Translational Initiation Proline-rich Region Binding Signal Transduction Sin3-type Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Metabolic Process Regulation Of TOR Signaling Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization Response To Nutrient Levels Regulation Of Primary Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Catabolic Process
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