SREK1 and ZRANB2

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SREK1	ZRANB2
Description		splicing regulatory glutamic acid and lysine rich protein 1	zinc finger RANBP2-type containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Lipopolysaccharide Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MRNA Processing RNA Splicing	RNA Processing MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Dental caries (decayed, missing and filled teeth) ( 31533690) Verbal declarative memory ( 25648963)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	17 interacting genes: AKAP17A CEBPA CSNK2A1 EP300 KIF20A LRRK2 OGT SMN1 SNRNP70 SREK1 SRPK1 SRPK2 SRSF2 TRA2B U2AF1 UBC YY1
Entrez ID		140890	9406
HPRD ID		18043	09185
Ensembl ID		ENSG00000153914	ENSG00000132485
Uniprot IDs		Q8WXA9	O95218
PDB IDs			1N0Z 2K1P 3G9Y
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	RNA Splicing MRNA Metabolic Process MRNA Processing RNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process RNA Binding Regulation Of RNA Splicing RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Spliceosomal Complex Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Nucleic Acid Binding Spliceosomal Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteasomal Protein Catabolic Process RNA Splicing, Via Transesterification Reactions STAT Family Protein Binding Regulation Of RNA Metabolic Process Chromatin DNA Binding Negative Regulation Of Autophagy Regulation Of Nucleobase-containing Compound Metabolic Process Sin3-type Complex Negative Regulation Of Protein Catabolic Process Regulation Of Gene Expression Histone Acetyltransferase Complex Nuclear Matrix Protein Kinase A Binding Regulation Of Macromolecule Biosynthetic Process PcG Protein Complex Protein Serine Kinase Activity Negative Regulation Of Proteolysis Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macrophage Activation Regulation Of Primary Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Autophagy Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Hemopoiesis Positive Regulation Of Proteolysis
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