NPM1 and PADI4

Number of citations of the paper that reports this interaction (PubMedID 19843866)
0

Data Source:
BioGRID (enzymatic study)

		NPM1	PADI4
Description		nucleophosmin 1	peptidyl arginine deiminase 4
Image
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling Protein Import Into Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Macrophage Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Regulation Of Cell Population Proliferation Ribosome Biogenesis Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Senescence Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Immune System Process Chromatin Organization Nucleosome Assembly Chromatin Remodeling Stem Cell Population Maintenance Protein Modification Process Post-translational Protein Modification Innate Immune Response
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SARS-CoV-1-host interactions ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer PKR-mediated signaling	Chromatin modifying enzymes
Drugs		Artenimol	Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide Chlortetracycline
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756 32912934) Rheumatoid arthritis ( 21452313 21505073 23143596 24390342 30423114 30572963 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		68 interacting genes: ABCC1 ACY1 ALK APP ARF1 ATM CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CHEK1 CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 GADD45A GGA1 GGA2 GGA3 GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NIBAN1 NOP2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIRT7 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 UBC UQCRH WEE2-AS1 XPO1 YY1	12 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 MDM2 NPM1 POU6F2 RYBP SMURF1 TRIB3
Entrez ID		4869	23569
HPRD ID		01246	05635
Ensembl ID		ENSG00000181163	ENSG00000159339
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 E5RI98 P06748	Q9UM07
PDB IDs		2LLH 2P1B 2VXD 5EHD 7OBG 7OBH 8AH2 8AS5	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B 8GOD 8R8U 8R8V 8SMK 8SML
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Response To Stress Protein Localization To Organelle Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Chromatin Binding Protein Localization To Site Of Double-strand Break Negative Regulation Of DNA Metabolic Process	Positive Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus Response To Catecholamine Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process NF-kappaB Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Dopamine Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Manganese Ion Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Golgi-associated Vesicle Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Programmed Cell Death
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