NPM1 and PADI4

Number of citations of the paper that reports this interaction (PMID 19843866)
18

Data Source:
BioGRID (enzymatic study)

		NPM1	PADI4
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	peptidyl arginine deiminase, type IV
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Deiminase Activity
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Chromatin Modification Protein Citrullination Stem Cell Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs			L-Citrulline N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS			Basal cell carcinoma ( 18849993) Rheumatoid arthritis ( 21452313 21505073)
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	6 interactors: ANXA4 APP FBXO25 HDAC2 HIST2H3A NPM1
Entrez ID		4869	23569
HPRD ID		01246	05635
Ensembl ID		ENSG00000181163	ENSG00000159339
Uniprot IDs		P06748	B2RBW0 Q9UM07
PDB IDs		2LLH 2P1B 2VXD	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Chromatin Silencing Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Coagulation Hemostasis ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Body Fluid Levels Gene Silencing Wound Healing Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Wounding Dendrite Development Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Maintenance Of Chromatin Silencing Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Neuron Differentiation Negative Regulation Of Interleukin-8 Secretion Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Gene Expression, Epigenetic Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of MHC Class II Biosynthetic Process Axon Choice Point Recognition Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Fungiform Papilla Morphogenesis
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Intersection) ?		next