SREK1 and SAFB

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SREK1	SAFB
Description		splicing regulatory glutamic acid and lysine rich protein 1	scaffold attachment factor B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Nucleoplasm Midbody
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding RNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	MRNA Processing RNA Splicing	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Estrogen Receptor Signaling Pathway Regulation Of MRNA Processing Regulation Of Androgen Receptor Signaling Pathway
Pathways			SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Mean reticulocyte volume ( 32888494)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	30 interacting genes: ABHD16A CDC37 CEBPA CHD1 CHD3 CLK1 CSNK2A1 CYCS ESR1 HNRNPA1 HNRNPD HNRNPK IL7R LINC00941 MIR199A1 MIR363 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7D NCOR1 POLR2A SAFB2 SREK1 SRPK1 SRPK2 SRSF9 SUMO2 TAF15 TJP2
Entrez ID		140890	6294
HPRD ID		18043	04205
Ensembl ID		ENSG00000153914	ENSG00000160633
Uniprot IDs		Q8WXA9	B7Z2F6 B7ZLP5 Q15424
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Metabolic Process Regulation Of RNA Splicing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Processing Post-transcriptional Gene Silencing Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RISC Complex Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression RNA Splicing MRNA Base-pairing Post-transcriptional Repressor Activity Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process Chromatin RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Protein Domain Specific Binding Positive Regulation Of Catabolic Process MRNA 3'-UTR Binding Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Processing DNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of MRNA Stability Nucleus Nucleic Acid Metabolic Process ATP-dependent Chromatin Remodeler Activity
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