SREK1 and RBMX

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SREK1	RBMX
Description		splicing regulatory glutamic acid and lysine rich protein 1	RNA binding motif protein X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck	Euchromatin Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Membrane Protein-containing Complex Organelle Supraspliceosomal Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription By RNA Polymerase II MRNA Processing Membrane Protein Ectodomain Proteolysis RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Homooligomerization Cellular Response To Interleukin-1
Pathways			mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Pediatric autoimmune diseases ( 26301688)
Interacting Genes		66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	51 interacting genes: APOBEC3C CCDC33 CEBPA CIRBP CLK1 CLK3 CMTM6 CNNM3 CSNK2A1 FOXP1 FXR2 HNRNPK IL7R ITSN2 JAK2 KHDRBS2 KHDRBS3 LINC01232 LNX1 MAGOHB MYPOP NABP1 NEIL3 NFE2L2 NXF1 NYX OGT PCBP2 PCDHB14 PRPF31 PRR3 PSMF1 PWARSN RAMAC RBM3 RBM7 RBMY1A1 RBMY1E RBMY1F RBMY1J ROBO3 SF1 SNRPA SOCS3 SORBS3 SREK1 SRPK2 STAT5A TRA2B XRN1 ZNF490
Entrez ID		140890	27316
HPRD ID		18043	02186
Ensembl ID		ENSG00000153914	ENSG00000147274
Uniprot IDs		Q8WXA9	P38159
PDB IDs			2MB0 2MKS
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of RNA Splicing Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Spliceosomal Complex RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Metabolic Process RNA Processing Positive Regulation Of MRNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Metabolic Process Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Interleukin-6-mediated Signaling Pathway MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Interleukin-5-mediated Signaling Pathway Cytoplasmic Stress Granule Thrombopoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Biosynthetic Process Response To Tumor Necrosis Factor Mammary Gland Epithelium Development Protein Domain Specific Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Proteasomal Protein Catabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT
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