NPM1 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 15684379)
86

Data Source:
HPRD (in vitro, in vivo)

		NPM1	ARF1
Description		nucleophosmin 1	ARF GTPase 1
Image
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling Protein Import Into Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Macrophage Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Regulation Of Cell Population Proliferation Ribosome Biogenesis Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Senescence Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SARS-CoV-1-host interactions ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer PKR-mediated signaling	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs		Artenimol	1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		68 interacting genes: ABCC1 ACY1 ALK APP ARF1 ATM CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CHEK1 CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 GADD45A GGA1 GGA2 GGA3 GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NIBAN1 NOP2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIRT7 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 UBC UQCRH WEE2-AS1 XPO1 YY1	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		4869	375
HPRD ID		01246	00054
Ensembl ID		ENSG00000181163	ENSG00000143761
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 E5RI98 P06748	P84077
PDB IDs		2LLH 2P1B 2VXD 5EHD 7OBG 7OBH 8AH2 8AS5	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Response To Stress Protein Localization To Organelle Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Gene Expression Cellular Response To Oxygen-containing Compound Chromatin Binding Protein Localization To Site Of Double-strand Break Negative Regulation Of DNA Metabolic Process	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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