Wiki-Pi
About
Search
People
Updates
Search
NPM1 and PLCG1
Number of citations of the paper that reports this interaction (PubMedID
9819383
)
49
Data Source:
BioGRID
(pull down, affinity chromatography technology)
NPM1
PLCG1
Description
nucleophosmin 1
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Granular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Focal Adhesion
Large Ribosomal Subunit
Small Ribosomal Subunit
Membrane
Nuclear Speck
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Molecular Function
Core Promoter Sequence-specific DNA Binding
Nucleic Acid Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
RRNA Binding
Protein Kinase Binding
Tat Protein Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
NF-kappaB Binding
Unfolded Protein Binding
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Biological Process
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Regulation Of Cell Growth
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
Protein Import Into Nucleus
Cell Volume Homeostasis
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Intracellular Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Macrophage Differentiation
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Endodeoxyribonuclease Activity
Cellular Response To UV
Regulation Of Cell Population Proliferation
Ribosome Biogenesis
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Negative Regulation Of MRNA Splicing, Via Spliceosome
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Cellular Senescence
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Protein Localization To Nucleolus
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SARS-CoV-1-host interactions
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
PKR-mediated signaling
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Drugs
Artenimol
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Multisite chronic pain (
33830993
)
Subcortical volume (MOSTest) (
32665545
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
68 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
ATM
CACYBP
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CHEK1
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
GADD45A
GGA1
GGA2
GGA3
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NIBAN1
NOP2
OGT
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SIRT7
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
UBC
UQCRH
WEE2-AS1
XPO1
YY1
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
4869
5335
HPRD ID
01246
01398
Ensembl ID
ENSG00000181163
ENSG00000124181
Uniprot IDs
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
E5RI98
P06748
P19174
PDB IDs
2LLH
2P1B
2VXD
5EHD
7OBG
7OBH
8AH2
8AS5
1HSQ
2HSP
4EY0
4FBN
7NXE
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Signal Transduction In Response To DNA Damage
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Protein Catabolic Process
Response To Stress
Protein Localization To Organelle
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Gene Expression
Cellular Response To Oxygen-containing Compound
Chromatin Binding
Protein Localization To Site Of Double-strand Break
Negative Regulation Of DNA Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?