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HIST2H3C and PKN1
Number of citations of the paper that reports this interaction (PMID
18066052
)
36
Data Source:
BioGRID
(enzymatic study)
HIST2H3C
PKN1
Gene Name
histone cluster 2, H3c
protein kinase N1
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Endosome
Plasma Membrane
Cytoplasmic Membrane-bounded Vesicle
Midbody
Cleavage Furrow
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
GTP-Rho Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Rac GTPase Binding
Androgen Receptor Binding
Biological Process
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Histone H3-T11 Phosphorylation
Regulation Of Cell Motility
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
40 interactors:
ACTN1
AKAP9
ARHGAP10
ARHGAP26
CASP3
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57L1
GOLGA2
HDAC5
HDAC6
HIST1H1A
HIST2H3C
HOMER3
KRT15
KRT31
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
NEFH
NEFL
NEUROD2
PDPK1
PLD1
RHOA
SPRR2D
SSX2IP
TNFRSF1B
TRAF1
TRAF2
VIM
WBSCR22
ZFAND6
ZNF282
Entrez ID
126961
5585
HPRD ID
11822
03019
Ensembl ID
ENSG00000123143
Uniprot IDs
Q71DI3
Q16512
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
1CXZ
1URF
2RMK
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Organelle Organization
Cytoskeleton Organization
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Cellular Response To Organic Substance
Response To Organic Substance
Response To Tumor Necrosis Factor
Regulation Of Microtubule-based Movement
Intermediate Filament Organization
Response To Growth Factor
Microtubule Cytoskeleton Organization
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cellular Process
Neurofilament Bundle Assembly
Response To Stress
Regulation Of Cellular Component Movement
Regulation Of Cell Death
Microtubule-based Process
Regulation Of Cell Differentiation
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Metabolic Process
Intermediate Filament Bundle Assembly
Defense Response
Epithelium Development
Intermediate Filament Cytoskeleton Organization
Cell Communication
Intermediate Filament-based Process
Microtubule-based Transport
Regulation Of Intracellular Signal Transduction
Anatomical Structure Development
Regulation Of Apoptotic Process
Cytoskeleton-dependent Intracellular Transport
Regulation Of Metabolic Process
Response To Wounding
Response To Stimulus
Regulation Of Cell Projection Organization
Response To Cytokine
Regulation Of Axonogenesis
Positive Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Signaling
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Cell Differentiation
Regulation Of Microtubule-based Process
Regulation Of Phosphorylation
Regulation Of Microtubule Polymerization Or Depolymerization
Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
accordingly
androgen
ar
blocks
chip
colocalization
driver
enriched
epigenomic
establishing
facilitates
h3k4
h3k4me3
h3t11p
hyperexpressed
integrator
interacts
marked
mll
mll1
promoters
prostate
recruitment
seq
set1
severely
threonine
tri
wdr5
Tagcloud (Difference)
?
accordingly
androgen
ar
blocks
chip
colocalization
driver
enriched
epigenomic
establishing
facilitates
h3k4
h3k4me3
h3t11p
hyperexpressed
integrator
interacts
marked
mll
mll1
promoters
prostate
recruitment
seq
set1
severely
threonine
tri
wdr5
Tagcloud (Intersection)
?