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H3C14 and PKN1
Number of citations of the paper that reports this interaction (PubMedID
18066052
)
19
Data Source:
BioGRID
(enzymatic study)
H3C14
PKN1
Description
H3 clustered histone 14
protein kinase N1
Image
GO Annotations
Cellular Component
Chromatin
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Membrane
Midbody
Cytoplasmic Vesicle
Cleavage Furrow
Protein-containing Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Histone H3T11 Kinase Activity
Histone Binding
Histone Deacetylase Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Nucleosome Assembly
Gene Expression
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Hyperosmotic Response
Signal Transduction
Epithelial Cell Migration
Negative Regulation Of B Cell Proliferation
Intracellular Signal Transduction
Post-translational Protein Modification
Positive Regulation Of DNA-templated Transcription
Spleen Development
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Cell Motility
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
Chromatin modifying enzymes
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Assembly of the ORC complex at the origin of replication
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RAC1 GTPase cycle
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
66 interacting genes:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CBX2
CBX4
CBX6
CBX7
CBX8
CDCA8
CDK8
CHUK
DDB2
DNAJC9
DNMT3L
EHMT2
ELP3
EP300
HDGFL2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
NAP1L4
NASP
NCOA6
NRDC
NSD2
PHF21A
PIM1
PKN1
PRMT6
PTMA
PWWP3A
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DNAAF19
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
RHOB
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
126961
5585
HPRD ID
11822
03019
Ensembl ID
ENSG00000203811
ENSG00000123143
Uniprot IDs
Q71DI3
Q16512
PDB IDs
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
4MZF
4MZG
4MZH
4OUC
5B0Y
5B0Z
5B40
5BO0
5CIU
5VAC
6ACE
6FML
6T79
6T7A
6T7B
6T7C
6T7D
6X59
6X5A
6XJD
6Y5D
6Y5E
7BQZ
7BU9
7JO9
7JOA
7JZV
7PET
7PEU
7PEV
7PEW
7PEX
7PEY
7PEZ
7PF0
7PF2
7PF3
7PF4
7PF5
7PF6
7PFA
7PFC
7PFD
7PFE
7PFF
7PFT
7PFU
7PFV
7PFW
7PFX
7TAN
7U50
7U51
7U52
7U53
7UV9
7UVA
7XCR
7XCT
7XD0
7YRD
8AAG
8ATF
8AV6
8GRQ
8HQY
8HR1
8JLB
8JLD
8OL1
8VMJ
8VMN
8VO0
8VOB
8VWS
8VWT
8VWU
8VWV
8X7I
8X7J
8X7K
9DWF
9DWG
9DWH
9DWI
9DWJ
9DWK
9DWL
9DWM
9GMK
9GMR
9IPU
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
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Chromatin Organization
Chromatin Remodeling
Nucleoplasm
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Chromatin Binding
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Chromosome
Positive Regulation Of Biosynthetic Process
Histone Binding
Histone Methyltransferase Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Histone H3K4 Monomethyltransferase Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone H3K4 Trimethyltransferase Activity
Transcription Coactivator Activity
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Chromatin
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Transferase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Histone H3 Methyltransferase Activity
Negative Regulation Of Biosynthetic Process
P53 Binding
Regulation Of Metaphase Plate Congression
Histone H3K4 Methyltransferase Activity
Methylation
Methyltransferase Activity
Acetyltransferase Activity
Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Organelle Organization
Keratin Filament
Morphogenesis Of An Epithelium
Structural Constituent Of Cytoskeleton
Cytosol
Identical Protein Binding
Structural Molecule Activity
Protein Binding
Tissue Morphogenesis
Microtubule Binding
Regulation Of Microtubule-based Process
Microtubule
Cytoplasm
Regulation Of Microtubule Cytoskeleton Organization
Centrosome
Epithelial Cell Differentiation
Developmental Process
Microtubule Cytoskeleton Organization
Epidermis Development
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Postsynaptic Intermediate Filament Cytoskeleton Organization
Neurofilament Bundle Assembly
Protein Localization To Cytoskeleton
Intermediate Filament Cytoskeleton
Cellular Component Assembly
Microtubule-based Process
Postsynaptic Intermediate Filament Cytoskeleton
Tumor Necrosis Factor Receptor Superfamily Complex
Cellular Developmental Process
Axon Development
Neurofibrillary Tangle
Regulation Of Synapse Maturation
Tumor Necrosis Factor Binding
Gamma-tubulin Binding
Intermediate Filament Bundle Assembly
Cell Projection Organization
Regulation Of Organelle Transport Along Microtubule
Response To Electrical Stimulus
Regulation Of Canonical NF-kappaB Signal Transduction
Neurofilament Cytoskeleton Organization
Thioesterase Binding
Focal Adhesion
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Tagcloud (Difference)
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Tagcloud (Intersection)
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