HIST2H3C and BIRC5

Number of citations of the paper that reports this interaction (PMID 20929775)
64

Data Source:
BioGRID (pull down, pull down)

		HIST2H3C	BIRC5
Gene Name		histone cluster 2, H3c	baculoviral IAP repeat containing 5
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytoplasm Centriole Spindle Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Ran GTPase Binding Tubulin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cofactor Binding Cobalt Ion Binding Chaperone Binding
	Biological Process	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Transcription, DNA-templated Protein Phosphorylation Chromosome Segregation Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Protein Ubiquitination Protein Complex Localization Positive Regulation Of Exit From Mitosis Spindle Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Chromosome Localization Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1	22 interactors: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CDCA8 CDK1 CDK4 DIABLO EVI5 HIST2H3C HIST3H3 HSP90AA1 INCENP KCNJ6 RASA1 XIAP XPO1
Entrez ID		126961	332
HPRD ID		11822	04520
Ensembl ID			ENSG00000089685
Uniprot IDs		Q71DI3	H3BLT4 O15392
PDB IDs		2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Cell Division Mitotic Cell Cycle Regulation Of Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitotic Nuclear Division Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Histone Phosphorylation Positive Regulation Of Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Cytokinesis Histone-serine Phosphorylation Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Zymogen Activation Cytokinesis Peptidyl-serine Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cell Cycle Process Positive Regulation Of Cysteine-type Endopeptidase Activity Spindle Stabilization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Mitotic Spindle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity
Tagcloud ?			autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?			autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?